292170-13-9
292170-13-9
Chemical Structure
OM137
- CAS. Nr.: 292170-13-9
- Formula:C13H14N4O3S
- Molecular Weight:306.34
IUPAC Name: (E)-2-amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methylthiazole-5-carbohydrazide
InChIKey: AMHQGUWEVRTTJB-GIDUJCDVSA-N
SMILES: O=C(N/N=C/C1=CC=C(C(OC)=C1)O)C2=C(N=C(S2)N)C
Biological Activity: OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes[1].
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OM137 | OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes. | |||||||||||||||||||||
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