1192754-38-3
Chemical Structure
IBPR002
- CAS No.: 1192754-38-3
- Formula:C34H36N6O4
- Molecular Weight:592.70
IUPAC Name: 1-(4-(2-((6-(4-(2-(4-hydroxypiperidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-phenylurea
InChIKey: WEVRAOPLGYJTLY-UHFFFAOYSA-N
SMILES: O=C(NC=1C=CC=CC1)NC2=CC=C(C=C2)CCNC=3N=CN=C4OC(=CC43)C=5C=CC(OCCN6CCC(O)CC6)=CC5
Biological Activity: IBPR002 is an inhibitor of Aurora kinase A and Aurora kinase B, with IC50 values of 41 nM and 17 nM, respectively. IBPR002 disrupts the nucleation and bundling of kinetochore microtubules, impairs the bipolarity of mitotic spindles, and promotes the binding of non-phosphorylated hepatoma up-regulated protein (HURP) to microtubules derived from the mother centrosome. IBPR002 reduces tumorigenesis levels in a colorectal cancer xenograft model using athymic nude mice. IBPR002 is applicable for research related to colorectal cancer[1].
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IBPR002 | IBPR002 is an inhibitor of Aurora kinase A and Aurora kinase B, with IC50 values of 41 nM and 17 nM, respectively. IBPR002 disrupts the nucleation and bundling of kinetochore microtubules, impairs the bipolarity of mitotic spindles, and promotes the binding of non-phosphorylated hepatoma up-regulated protein (HURP) to microtubules derived from the mother centrosome. IBPR002 reduces tumorigenesis levels in a colorectal cancer xenograft model using athymic nude mice. IBPR002 is applicable for research related to colorectal cancer. | |||||||||||||||||||||
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Keywords
