Cytochalasin J
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC50 of 1.5 μM.
For research use only. We do not sell to patients.
- CAS No.: 53760-20-6
- Formula: C28H37NO4
- Molecular Weight:451.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: 17
|
Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| HepG2 | IC50 |
>50 μM
Compound: 17
|
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| MDA-MB-231 | IC50 |
31 μM
Compound: 17
|
Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| MDA-MB-435 | IC50 |
4.9 μM
Compound: 17
|
Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| SNB-19 | IC50 |
6.8 μM
Compound: 17
|
Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| Vero | IC50 |
>50 μM
Compound: 17
|
Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
Chemical Information
-
CAS No. 53760-20-6
-
Molecular Weight 451.60
-
Formula C28H37NO4
-
SMILES
O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C
-
Structure Classification
-
Initial Source
Endothia gyrosa IFB-E023
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xu S, et al., Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem Biodivers. 2009 May;6(5):739-45. [Content Brief]
[2]. Wrench GA, et al., Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. Cell Motil Cytoskeleton. 1997;36(2):112-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cytochalasin J Related Classifications
HY-126556 Related Classifications
Powered by Bioz