SKA3 Antibody (YA7014)
(Synonyms: C13orf3 antibody; RAMA1 antibody; SKA3 antibody; SKA3_HUMAN antibody; Spindle and kinetochore associated complex subunit 3 antibody; Spindle and kinetochore-associated protein 3 antibody)
Based on 1 Customer Validation
SKA3 Antibody (YA7014) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SKA3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:100-1:1000 | 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) | 1:50-1:500 |
Product Details
SKA3 Antibody (YA7014) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SKA3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 46kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 46kDa
Amino acids 154-166 within an internal region of Ska3 of human origin
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
SKA3 component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton, spindle,Chromosome, centromere, kinetochore
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Isoforms & Post-Translational Modification
Q8IX90 has three isomers: Q8IX90-1: 46359 Da (predicted); Q8IX90-2: 3827 Da (predicted); Q8IX90-3: 43978 Da (predicted).
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Subunit
Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3 (PubMed:19289083, PubMed:19360002)
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SwissProt ID
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Synonyms
C13orf3 antibody; RAMA1 antibody; SKA3 antibody; SKA3_HUMAN antibody; Spindle and kinetochore associated complex subunit 3 antibody; Spindle and kinetochore-associated protein 3 antibody
Documentation
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Data Sheet (231 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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User Guide for Antibodies (1077 KB)
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