CENPF Antibody (YA9690)
(Synonyms: AH antigen, Cell cycle dependent 350K nuclear protein, CENF, CENP F, CENP F kinetochore protein, CENP-F, CENPF, CENPF kinetochore protein, CENPF_HUMAN, Centromere protein F 350/400ka)CENPF Antibody (YA9690) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to CENPF.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:1000 |
Product Details
CENPF Antibody (YA9690) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to CENPF.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 358 kDa;
Recombinant protein of human CENPF (aa 2825-3114).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CENPF is required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia
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Subcellular Localization
Cytoplasm, perinuclear region; Nucleus matrix; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle
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Isoforms & Post-Translational Modification
CENPF has an amino acid length of 3114, molecular weight is 357527 Da.
Hyperphosphorylated during mitosis -
Subunit
Interacts with and STX4 (via C-terminus) (By similarity).
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SwissProt ID
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Synonyms
AH antigen, Cell cycle dependent 350K nuclear protein, CENF, CENP F, CENP F kinetochore protein, CENP-F, CENPF, CENPF kinetochore protein, CENPF_HUMAN, Centromere protein F 350/400ka
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