342595-74-8
Chemical Structure
UMK57
- CAS No.: 342595-74-8
- Formula:C17H17N3S
- Molecular Weight:295.40
IUPAC Name: 4-(pyrrolidin-1-yl)-5-(p-tolyl)thieno[2,3-d]pyrimidine
InChIKey: VOAWQTDHSSKEKA-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CSC3=NC=NC(N4CCCC4)=C32
Biological Activity: UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UMK57 | 99.51% | UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors. | ||||||||||||||||||||
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- [1]. Kucharski TJ, et al. An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity. Cell Rep. 2025;44(2):115317. [Content Brief]
- [2]. Orr B, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763. [Content Brief]
Keywords
