1 Result for "

marein

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "marein" in MCE Product Catalog:

3
Marein
Marein
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3 Cited Publications
Cat. No.: HY-N7676
CAS No.: 535-96-6
Category:  

Cardiovascular Disease other families Flavonoids Chalcones Neurological Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

AMPK HDAC

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .
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