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methiodide

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By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) Drug Derivative (2) Drug Metabolite (1) EGFR (1) GABA Receptor (2) Interleukin Related (1) Isotope-Labeled Compounds (1) mAChR (2) MMP (1) nAChR (1) Opioid Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103474

Bicuculline methiodide 4 Publications Verification (-)-Bicuculline methiodide	GABA Receptor	Neurological Disease
Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABA_A blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca ²⁺ -activated K ⁺ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca ²⁺ -activated K ⁺ current .

HY-100958

4-DAMP 4 Publications Verification 4-DAMP methiodide	mAChR Apoptosis MMP EGFR Interleukin Related	Inflammation/Immunology Cancer
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .

HY-150123

Quinidine methiodide	Drug Metabolite	Cardiovascular Disease
Quinidine methiodide is a metabolite of Quinidine. Quinidine is an antiarrhythmic agent .

HY-137279

Naloxone methiodide 1 Publications Verification	Opioid Receptor	Inflammation/Immunology
Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier .

HY-W743629

*Quinidine Methiodide-d3*	Isotope-Labeled Compounds	Others
Quinidine Methiodide-d₃ is the deuterium labeled Quinidine Methiodide.

HY-101361

Lidocaine methiodide Methyllidocaine iodide	Drug Derivative	Neurological Disease
Lidocaine methiodide (Methyllidocaine iodide) is a potent antiarrythmic agent, and is a derivative of Lidocaine (HY-B0185). Lidocaine methiodide can be used for the research of ventricular arrhythmias produced by coronary occlusion .

HY-N7784

Liriodenine methiodide	Antibiotic Bacterial	Infection
Liriodenine methiodide is an antibiotic that is active against *C. albicans* and *S. cereuisiae* with antimicrobial activities .

HY-N1064

Xanthoplanine	nAChR	Neurological Disease
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

HY-103474R

*Bicuculline methiodide* (Standard)** (-)-Bicuculline methiodide (Standard)	Reference Standards GABA Receptor	Neurological Disease
Bicuculline methiodide (Standard) is the analytical standard of Bicuculline methiodide (HY-103474). This product is intended for research and analytical applications. Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABAA blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current .

HY-167107

Methamilane methiodide	mAChR	Others
Methamilane methiodide is a potent muscarinic receptor agonist .

HY-137052

Lycorine methiodide N-Methyllycorine iodide	Drug Derivative	Cancer
Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC₅₀ values greater than 10 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7784

Liriodenine methiodide	Alkaloids Other Alkaloids Magnoliaceae Liriodendron tulipifera L. Plants Source Classification	Antibiotic Bacterial
Liriodenine methiodide is an antibiotic that is active against *C. albicans* and *S. cereuisiae* with antimicrobial activities .

HY-N1064

Xanthoplanine	Alkaloids Monophenols other families Phenols Plants Isoquinoline Alkaloids Source Classification	nAChR
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

Cat. No.	Product Name	Chemical Structure

HY-W743629

*Quinidine Methiodide-d3*
Quinidine Methiodide-d₃ is the deuterium labeled Quinidine Methiodide.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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methiodide

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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