94-23-5
Chemical Structure
Parethoxycaine
Synonym(s): Intracaine
- CAS No.: 94-23-5
- Formula:C15H23NO3
- Molecular Weight:265.35
InChIKey: OWWVHQUOYSPNNE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)OCC)OCCN(CC)CC
Biological Activity: Parethoxycaine (Intracaine) is an ester-type local anesthetic that possesses dual activities as a non-selective inhibitor and agonist potentiator in smooth muscle, while acting as a mixed-type inhibitor of cytochrome c oxidase at the enzyme level. Parethoxycaine non-competitively inhibits the contraction of guinea pig ileal longitudinal muscle by interfering with transmembrane Ca2+ transport (blocking K+/CD responses in an equi-effective manner), and potentiates norepinephrine (NA) responses in rat vas deferens by blocking NA uptake and promoting Ca2+ mobilization (increasing the maximum amplitude without affecting K+ responses). Parethoxycaine inhibits the activity of purified cytochrome c oxidase in a concentration-dependent manner, and can be used in research focusing on Ca2+ signal transduction, smooth muscle contraction regulation, and mitochondrial energy metabolism[1][2].
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Parethoxycaine | Parethoxycaine (Intracaine) is an ester-type local anesthetic that possesses dual activities as a non-selective inhibitor and agonist potentiator in smooth muscle, while acting as a mixed-type inhibitor of cytochrome c oxidase at the enzyme level. Parethoxycaine non-competitively inhibits the contraction of guinea pig ileal longitudinal muscle by interfering with transmembrane Ca2+ transport (blocking K+/CD responses in an equi-effective manner), and potentiates norepinephrine (NA) responses in rat vas deferens by blocking NA uptake and promoting Ca2+ mobilization (increasing the maximum amplitude without affecting K+ responses). Parethoxycaine inhibits the activity of purified cytochrome c oxidase in a concentration-dependent manner, and can be used in research focusing on Ca2+ signal transduction, smooth muscle contraction regulation, and mitochondrial energy metabolism. | |||||||||||||||||||||
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- [1]. Casanovas AM, et al. Inhibition of cytochrome oxidase activity by local anaesthetics. Biochemical pharmacology. 1983 Sep 15;32(18):2715-9. [Content Brief]
- [2]. Triggle CR, et al. Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle. Canadian journal of physiology and pharmacology. 1979 Aug;57(8):804-18. [Content Brief]
Keywords
