6 Results for "

mitochondrial Fe2

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "mitochondrial Fe2" in MCE Product Catalog:

7
Mito-FerroGreen
Mito-FerroGreen
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7 Publications Verification
Cat. No.: HY-D2295
Mito-FerroGreen is a mitochondria-specific Fluorescent indicator used to detect mitochondrial Fe 2+ levels (excitation: 488 nm; emission: 500-550 nm). Mito-FerroGreen can be applied to research related to colorectal cancer and chronic heart failure .
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Bleomycin A5
Bleomycin A5
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1 Cited Publications
Cat. No.: HY-N10470
CAS No.: 11116-32-8
Synonyms: Pingyangmycin
Category:  

Natural Products Microorganisms Animals

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .
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Cisd2 agonist 2
Cisd2 agonist 2
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1 Cited Publications
Cat. No.: HY-155539
CAS No.: 2916371-59-8
Pureté:  99.17%
Target:  

IKZF Family Zinc Finger Protein

Domaines de recherche:  

Inflammation/Immunology

Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
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Bleomycin A5 hydrochloride
Bleomycin A5 hydrochloride
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Cat. No.: HY-125918
CAS No.: 55658-47-4
Synonyms: Pingyangmycin hydrochloride
Category:  

Microorganisms Antibiotics

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .
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7-Ketositosterol
7-Ketositosterol
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Cat. No.: HY-N2757
CAS No.: 2034-74-4
Category:  

Plants Moraceae Morus alba Linn. Steroids

Target:  

Apoptosis Ferroptosis ERK NF-κB p38 MAPK Reactive Oxygen Species (ROS)

7-Ketositosterol is an orally active inducer of apoptosis and ferroptosis. 7-Ketositosterol inhibits the phosphorylation of ERK1/2 and NF-κB, promotes the opening of the mitochondrial/apoptotic pathway, and induces ferroptosis in macrophages by increasing the levels of malondialdehyde, Fe 2+ and ROS. 7-Ketositosterol upregulates the expression of gut microbiota-dependent PDLIM3, activates the p38MAPK/NF-κB signaling pathway, alters the composition of gut microbiota, increases the abundance of pathogenic bacteria, and exacerbates colitis in mice. 7-Ketositosterol can be used in studies related to breast cancer, liver cancer, and colitis .
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Ferroptosis/apoptosis inducer-3
Ferroptosis/apoptosis inducer-3
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Cat. No.: HY-179016
Target:  

Ferroptosis Apoptosis Mitochondrial Metabolism Calcium Channel

Domaines de recherche:  

Cancer

Ferroptosis/apoptosis inducer-3 (Compound 34) is a Ferroptosis and Apoptosis inducer. Ferroptosis/apoptosis inducer-3 induces both Ferroptosis and Apoptosis by causing G2/M phase cell cycle arrest, disrupting mitochondrial membrane potentials, promoting lipid peroxidation, and increasing the levels of Ca 2+ and Fe 2+ through the activation of calcium/calmodulin signaling. Ferraplasm/apoptosis inducer-3 shows anticancer effects against cervical cancer, adenocarcinoma, breast cancer, colon cancer, and colorectal carcinoma .
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