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Results for "

mucosal protective

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ANGPTL (1) AP-1 (1) Apoptosis (3) Bacterial (2) Cannabinoid Receptor (1) Caspase (2) Drug Derivative (1) Endogenous Metabolite (4) Environmental Pollutants (1) Histamine Receptor (5) Interleukin Related (4) Isotope-Labeled Compounds (1) NF-κB (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Ser/Thr Protease (1) TRP Channel (2) VEGFR (1)
By Research Areas:	Cancer (2) Endocrinology (5) Infection (2) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (1)
Oligonucleotides:	Thickeners (1) Suspending Agents (1) Disintegrants (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1310

Sodium alginate 1 Publications Verification	Environmental Pollutants	Others Cancer
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects .

HY-B0327

Irsogladine 3 Publications Verification Dicloguamine	Phosphodiesterase (PDE) NF-κB AP-1 TRP Channel Interleukin Related	Inflammation/Immunology Cancer
Irsogladine (Dicloguamine) is an orally active gastric mucosal protective agent. Irsogladine inhibits breast cancer recurrence and lung metastasis in nude mice . Irsogladine inhibits the transcriptional activities of NF-κB and AP-1, suppresses the activities of PDE and PDE4 to elevate intracellular cAMP levels, and activates TRPV1 and K_ATP channels. Irsogladine enhances iNOS expression, NO production, and the activation of cAMP-responsive elements. Irsogladine inhibits the development and progression of intestinal polyps in Apc-mutant mice. Irsogladine alleviates oxidative stress, increases gastric mucosal blood flow, and stimulates the production of endogenous prostaglandins. Irsogladine promotes insulin secretion in MIN6 cells. Irsogladine inhibits tumor angiogenesis, cancer cell proliferation, and the production of proinflammatory cytokines. Irsogladine exerts protective effects on astrocytes in ethanol/hydrochloric acid-induced gastric ulcers in mice. Irsogladine prevents colitis in IL-10 gene-deficient mice by reducing the production of IL-12 and IL-23. Irsogladine upregulates gap junction intercellular communication in pancreatic cancer cells via the PKA pathway. Irsogladine is applicable to research related to breast cancer, intestinal polyposis, gastric ulcer, spontaneous colitis, glioma, liver cancer, and pancreatic cancer ^[5][6] .

HY-B0160

Lafutidine FRG-8813	Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H₂RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

HY-103325

JTE-907	Cannabinoid Receptor TRP Channel Interleukin Related ANGPTL VEGFR	Metabolic Disease Inflammation/Immunology
JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis .

HY-145453

Propacetamol	Interleukin Related	Inflammation/Immunology
Propacetamol is an orally active prodrug of Acetaminophen (HY-66005), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) (HY-14654)-induced elevation of malondialdehyde (MDA) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione (GSH and GSSG) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid (UA) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress .

HY-122762

Cetraxate hydrochloride DV-1006	Ser/Thr Protease	Inflammation/Immunology
Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research . Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a K_i and an IC₅₀ of 0.94 μM and 3.3 μM, respectively .

HY-120314

GEA 3162	Apoptosis Caspase Endogenous Metabolite	Inflammation/Immunology
GEA 3162 is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 can be used for research on inflammatory conditions such as gastric ulcers .

HY-116953

Lipoxin B4 LXB4	Endogenous Metabolite	Inflammation/Immunology
Lipoxin B4 (LXB4) is a structurally distinct product of arachidonic acid metabolism. Lipoxin B4 reduces leukocyte infiltration and mucus secretion in the nasal mucosa and decreases mast cell and eosinophil degranulation in the upper airway. Lipoxin B4 decreases airway inflammation, mucus metaplasia and hyper- responsiveness in the lower airway. Lipoxin B4 shows mucosal protective actions and has the potential for the research of allergic inflammation in the upper and lower airways .

HY-19048

CP-66948	Histamine Receptor	Endocrinology
CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.

HY-N16660

Tangshenoside V	Drug Derivative	Neurological Disease Inflammation/Immunology
Tangshenoside V is a phenylpropanoid glucoside found in the roots of Codonopsis tangshen. Tangshenoside V has potential anti-inflammatory, immunomodulatory and mucosal protective effects. Tangshenoside V can be used for the researches of inflammation, immunology and neurological disease .

HY-B0160R

Lafutidine (Standard) FRG-8813 (Standard)	Reference Standards Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine (Standard) is the analytical standard of Lafutidine. This product is intended for research and analytical applications. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H₂RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

HY-121406

(Z)-Lafutidine (Z)-FRG-8813	Histamine Receptor	Inflammation/Immunology
(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities .

HY-107247

Escin IIb	Others	Inflammation/Immunology
Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals . Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions .

HY-145453R

Propacetamol (Standard)	Reference Standards Interleukin Related	Inflammation/Immunology
Propacetamol (Standard) is the analytical standard of Propacetamol (HY-145453). This product is intended for research and analytical applications. Propacetamol is an orally active prodrug of Acetaminophen (HY-66005), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) (HY-14654)-induced elevation of malondialdehyde (MDA) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione (GSH and GSSG) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid (UA) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress .

HY-B0160S

Lafutidine-d10	Isotope-Labeled Compounds Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine-d₁₀ is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

HY-135759

Cetraxate	Bacterial	Infection
Cetraxate is an orally active antiulcer Drug. Cetraxate increases the blood flow of gastric mucosal. Cetraxate increases the eradication of Helicobacter pylori in smokers when in combination with Omeprazole (HY-B0113),Amoxicillin (HY-B0467A), and Clarithromycin (HY-17508) .

HY-165489

AU-006	Endogenous Metabolite	Inflammation/Immunology Endocrinology
AU-006 is an orally active inhibitor of gastric acid secretion, with anti-ulcer effects. AU-006 does not rely on NO and mucus regulation. AU-006 significantly prevents 95% of gastric mucosal damage caused by ethanol and has broad-spectrum protective effects against chemical corrosive damage. AU-006 can be used for research on gastric ulcers . .

HY-170937

Urease-IN-20	Bacterial Apoptosis Reactive Oxygen Species (ROS)	Infection
Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori). Urease-IN-20 inhibits H. pylori with an IC₅₀ of 0.14 μM. Urease-IN-20 reduces cell Apoptosis and decreases ROS and γH2AX in GES-1 cells infected with H. pylori. Urease-IN-20 exhibits significant gastric mucosal protective effects. Urease-IN-20 shows the potential for H. pylori research .

HY-120314A

GEA 3162 hydrochloride	Apoptosis Caspase Endogenous Metabolite	Inflammation/Immunology
GEA 3162 hydrochloride is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 hydrochloride significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 hydrochloride induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 hydrochloride has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 hydrochloride can be used for research on inflammatory conditions such as gastric ulcers .

HY-N13073

6-Gingediol	Others	Others
6-Gingediol (compound 13) is a pungent component of ginger with potential anti-serotonin and gastric mucosal protective effects. 6-Gingediol has no pungent effect at concentrations below 10 μM, but the pungent effect is significant at concentrations above 100 μM or even 1000 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1310

Sodium alginate 1 Publications Verification	Marine natural products Source Classification	Environmental Pollutants
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects .

HY-N16660

Tangshenoside V	Structural Classification Monophenols Campanulaceae Phenols Plants Codonopsis pilosula subsp. tangshen (Oliv.) D. Y. Hong Source Classification	Drug Derivative
Tangshenoside V is a phenylpropanoid glucoside found in the roots of Codonopsis tangshen. Tangshenoside V has potential anti-inflammatory, immunomodulatory and mucosal protective effects. Tangshenoside V can be used for the researches of inflammation, immunology and neurological disease .

HY-107247

Escin IIb	Triterpenes Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals . Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions .

HY-N13073

6-Gingediol	Zingiber officinale Roscoe Monophenols Phenols Plants Source Classification Zingiberaceae	Others
6-Gingediol (compound 13) is a pungent component of ginger with potential anti-serotonin and gastric mucosal protective effects. 6-Gingediol has no pungent effect at concentrations below 10 μM, but the pungent effect is significant at concentrations above 100 μM or even 1000 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0160S

Lafutidine-d10
Lafutidine-d₁₀ is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

Cat. No.	Product Name		Classification

HY-Y1310

Sodium alginate 1 Publications Verification		Thickeners Disintegrants Suspending Agents
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects .

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mucosal protective

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products