2. Search Result
Search Result
Results for "

nonsense mutations

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114231B
    Exaluren disulfate
    2 Publications Verification

    ELX-02 disulfate; NB-124 disulfate

    		 DNA/RNA Synthesis Inflammation/Immunology
    Exaluren (ELX-02; NB-124) disulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren disulfate is used for the research of cystic fibrosis caused by nonsense mutations .
    Exaluren disulfate
  • HY-159641
    VVD-130037

    BAY-3605349

    		 Molecular Glues Keap1-Nrf2 Metabolic Disease Inflammation/Immunology Cancer
    VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors .
    VVD-130037
  • HY-161111
    KVS0001

    		Ser/Thr Kinase Cancer
    KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases .
    KVS0001
  • HY-118341
    Clitocine

    		Apoptosis Bcl-2 Family Cancer
    Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .
    Clitocine
  • HY-114231
    Exaluren
    2 Publications Verification

    ELX-02; NB-124

    		 Drug Derivative Inflammation/Immunology
    Exaluren (ELX-02; NB-124) is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .
    Exaluren
  • HY-150089
    SRI-37240

    		CFTR Inflammation/Immunology
    SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .
    SRI-37240
  • HY-101203
    GJ103

    		Drug Derivative Metabolic Disease Cancer
    GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations .
    GJ103
  • HY-101203A
    GJ103 sodium
    1 Publications Verification

    		 DNA/RNA Synthesis Metabolic Disease Cancer
    GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .
    GJ103 sodium
  • HY-177569
    NVS1.1

    		Eukaryotic Initiation Factor (eIF) Others
    NVS1.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS1.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS1.1 can be used for the research of genetic diseases caused by nonsense mutations .
    NVS1.1
  • HY-123359
    RTC14

    		DNA/RNA Synthesis Dystrophin Others
    RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .
    RTC14
  • HY-177963
    NV914

    		DNA Methyltransferase Inflammation/Immunology
    NV914 is an inhibitor of FTSJ1 (tryptophan tRNA-specific 2'-O-methyltransferase) that inhibits the methyltransferase activity of FTSJ1, induces translational readthrough of premature termination codons, and enables genes carrying nonsense mutations to synthesize full-length proteins. NV914 belongs to translational readthrough-inducing compounds (TRIDs). NV914 exhibits translational readthrough activity against nonsense mutations in in vitro systems, does not induce readthrough of natural termination codons, and restores CFTR protein expression. NV914 shows favorable acute oral tolerance in mice, with low health risks and good safety profiles. NV914 is applicable to research related to cystic fibrosis and Shwachman-Diamond syndrome .
    NV914
  • HY-177757
    NVS2.1

    		Eukaryotic Initiation Factor (eIF) Others
    NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations .
    NVS2.1
  • HY-114231C
    Exaluren sulfate

    ELX-02 sulfate; NB-124 sulfate

    		 Drug Derivative Metabolic Disease
    Exaluren (ELX-02; NB-124) sulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren sulfate is used for the research of cystic fibrosis caused by nonsense mutations .
    Exaluren sulfate
  • HY-126210
    GJ072

    		Biochemical Assay Reagents Others
    GJ072 is a read-through compound (RTCs). GJ072 can induce “readthrough” .
    GJ072
  • HY-157468
    (R)-ELX-02

    		Others Others
    (R)-ELX-02, also referred to as NB-124, is an eukaryotic ribosomal selective glycoside (ERSG) engineered to enhance read-through activity in patients with nonsense mutations, facilitating the generation of adequate levels of full-length functional protein.
    (R)-ELX-02
  • HY-118341R
    Clitocine (Standard)

    		Reference Standards Apoptosis Bcl-2 Family Cancer
    H-Chpro-OH.HCl (Standard) is the analytical standard of H-Chpro-OH.HCl. This product is intended for research and analytical applications. H-Chpro-OH.HCl is a proline derivative .
    Clitocine (Standard)
  • HY-101203AR
    GJ103 sodium (Standard)

    		DNA/RNA Synthesis Reference Standards Metabolic Disease Cancer
    GJ103 (sodium) (Standard) is the analytical standard of GJ103 (sodium) (HY-101203A). This product is intended for research and analytical applications. GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .
    GJ103 sodium (Standard)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: