3056394-59-0
Chemical Structure
KVS0001
- CAS No.: 3056394-59-0
- Formula:C27H27ClN8O3S
- Molecular Weight:579.07
InChIKey: ZEGVOEXOEQDDKK-UHFFFAOYSA-N
SMILES: ClC1=C(S(N2CCNCC2)(=O)=O)C=C(NC3=NC=CC(C4=CC(C5=CC=C(NC(NC)=O)C=C5)=NC=C4)=N3)C=C1
Biological Activity: KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KVS0001 | 99.11% | KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases. | ||||||||||||||||||||
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Keywords
