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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
nuclear pore
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "nuclear pore" in MCE Product Catalog:
Cat. No.: HY-170430
CAS No.: 3055558-98-7
Target:
Research Areas:
HGC652 is a molecular glue degrader targeting TRIM21 with a TRIM21-dependent nuclear membrane disruption effect. HGC652 binds to the PRY-SPRY domain of TRIM21 with high affinity (Ka=0.061 μM), mediates the interaction between TRIM21 and NUP98, and redirects E3 ligase activity. By triggering the polyubiquitination and proteasomal degradation of nucleoporins (such as NUP155 and GLE1), HGC652 disrupts nuclear membrane integrity, alters nuclear morphology, induces genomic instability, and thereby induces cancer cell death .
Cat. No.: HY-119264
CAS No.: 903499-49-0
Research Areas:
PRLX-93936 is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 inhibits HIF-1 under hypoxic conditions (IC50 = 0.09 μM in cell-based reporter gene assay). PRLX-93936 suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 is applicable to research related to pancreatic cancer and multiple myeloma .
Cat. No.: HY-W010514
CAS No.: 1460-57-7
Target:
Research Areas:
PRLX-93936 dihydrochloride is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 dihydrochloride binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 dihydrochloride induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 dihydrochloride inhibits HIF-1 under hypoxic conditions (IC50 = 0.09 μM in cell-based reporter gene assay). PRLX-93936 dihydrochloride suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 dihydrochloride is applicable to research related to pancreatic cancer and multiple myeloma .
Cat. No.: HY-186250
CAS No.: 3055559-33-3
Target:
Research Areas:
TRIM21 ligand-1 is a TRIM21 ligand. TRIM21 ligand-1 mediates the degradation of nuclear pore complex proteins GLE1 and NUP155. TRIM21 ligand-1 induces the disassembly of nuclear pore complexes, which in turn leads to cell death. TRIM21 ligand-1 can be used in cancer research .
Cat. No.: HY-P72263
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP210; nuclear pore Membrane Glycoprotein 210; Nucleoporin 210; pore Membrane Protein Of 210 KDa; POM210; nuclear pore Protein Gp210; KIAA0906; Nucleoporin 210kDa; GP210; Nucleoporin Nup210; nuclear Envelope pore Membrane Protein POM 210; FLJ22389
Cat. No.: HY-P77109
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP210; nuclear pore Membrane Glycoprotein 210; Nucleoporin 210; pore Membrane Protein Of 210 KDa; POM210; nuclear pore Protein Gp210; KIAA0906; Nucleoporin 210kDa; GP210; Nucleoporin Nup210; nuclear Envelope pore Membrane Protein POM 210; FLJ22389
Species:
Source:
Cat. No.: HY-P703291
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NUP50; Nucleoporin Nup50; Prev. NPAP60L; nuclear pore-Associated Protein 60L; nuclear pore Complex Protein Nup50; Nucleoporin 50kD; 50 KDa Nucleoporin; NPAP60; Nucleoporin 50kDa; Nucleoporin 50; nuclear pore-Associated Protein 60 KDa-Like
Cat. No.: HY-W010514R
CAS No.: 1460-57-7
Category:
Cat. No.: HY-P703236
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NUP214; Nucleoporin Nup214; Nucleoporin 214; D9S46E; nuclear pore Complex Protein Nup214; N214; CAIN; CDNA, FLJ79316, Highly Similar To nuclear pore Complex Protein Nup214; CAN; Nucleoporin 214kD (CAIN); CAN Protein, Putative Oncogene; Protein CAN; 214 KD
Cat. No.: HY-P81292
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup96; nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P81292A
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup96; nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P85549
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup96; nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P81292AA
Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup96; nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN.
Cat. No.: HY-P11489
CAS No.: 252731-57-0
Research Areas:
Cat. No.: HY-P705107
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NUP85; FLJ12549; Nucleoporin 85; FROUNT; NUP75; 85 KDa Nucleoporin; nuclear pore Complex Protein Nup85; Pericentrin-1; Nucleoporin 85kDa; NPHS17; Nucleoporin Nup75; PCNT1; Nucleoporin Nup85
Cat. No.: HY-180654
CAS No.: 3110272-60-8
Target:
Research Areas:
JWZ-8-103 is an orally active analog of PRLX-93936 (HY-119264) and a molecular glue targeting TRIM21. JWZ-8-103 increases the thermal stability of TRIM21. JWZ-8-103 promotes rapid and efficient interaction between TRIM21 and NUP98 (the apparent EC50 for ternary complex formation with the PRYSPRY domain of TRIM21 and the APD domain of NUP98 is approximately 20 μM), induces extensive ubiquitination and proteasomal degradation of numerous adjacent nucleoporins (NUPs, and thereby triggers cellular apoptosis. JWZ-8-103 can be used for the research of pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
