TRIM21 ligand-1
TRIM21 ligand-1 is a TRIM21 ligand. TRIM21 ligand-1 mediates the degradation of nuclear pore complex proteins GLE1 and NUP155. TRIM21 ligand-1 induces the disassembly of nuclear pore complexes, which in turn leads to cell death. TRIM21 ligand-1 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3055559-33-3
- Formula: C22H21FN2O5S
- Molecular Weight:444.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TRIM21 ligand-1 (the last structural formula on page 7) is a ligand of TRIM21, an E3 ligase belonging to the tripartite motif family[1].
TRIM21 contains an N-terminal RING domain, a central Coiled-coiled domain, and a C-terminal PRYSPRY domain, where the RING domain is responsible for catalyzing ubiquitin transfer, and the PRY-SPRY domain functions in substrate recognition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3055559-33-3
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Molecular Weight 444.48
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Formula C22H21FN2O5S
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SMILES
O=C1C=C(CN(C)C(C2=C(S(=O)(C)=O)C=C(C3=CC=C(C=C3OC)F)C=C2)=O)C=CN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRIM21 ligand-1 Related Classifications
HY-186250 Related Classifications
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