234 Results for "

payloads

" in MedChemExpress (MCE) Product Catalog:
Products (234)

234 Results for "payloads" in MCE Product Catalog:

76
SN-38
SN-38
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76 Publications Verification
Cat. No.: HY-13704
CAS No.: 86639-52-3
Purity:  99.94%
Synonyms: 7-Ethyl-10-hydroxycamptothecin
Category:  

Alkaloids Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Cancer

Target:  

Drug Metabolite Topoisomerase ADC Payloads Autophagy

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .
7
Tesirine
Tesirine
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7 Cited Publications
Cat. No.: HY-128952
CAS No.: 1595275-62-9
Purity:  98.10%
Synonyms: SG3249
Target:  

Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
3
SG3199
SG3199
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3 Cited Publications
Cat. No.: HY-101161
CAS No.: 1595275-71-0
Purity:  98.94%
Target:  

DNA Alkylator/Crosslinker ADC Payloads

Research Areas:  

Cancer

SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
3
SPDB-DM4
SPDB-DM4
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3 Cited Publications
Cat. No.: HY-12460
CAS No.: 1626359-62-3
Purity:  98.14%
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.
3
Trastuzumab vedotin
Trastuzumab vedotin
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3 Cited Publications
Cat. No.: HY-164992
Synonyms: MRG002; Trastuzumab MMAE
Trastuzumab vedotin (MRG002; Trastuzumab MMAE) is an antibody-drug conjugate and cytotoxin targeting HER2, with a Kd of 7.50E-11 M for human HER2. After binding to HER2, Trastuzumab vedotin undergoes internalization and lysosomal trafficking, delivering a cytotoxic payload to HER2-expressing cells and inducing tumor regression in in vivo xenograft models with HER2-expressing tumors. The anti-tumor activity of Trastuzumab vedotin is enhanced when used in combination with anti-PD-1 antibodies, and it exhibits preclinical anti-tumor activity in drug-resistant breast cancer, gastric cancer, and urothelial carcinoma PDX models. Trastuzumab vedotin has low antibody-dependent cellular cytotoxicity activity and can be used in studies related to HER2-positive breast cancer, HER2-positive gastric cancer, and unresectable locally advanced or metastatic HER2-positive urothelial carcinoma .
2
Thailanstatin A
Thailanstatin A
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2 Cited Publications
Cat. No.: HY-129589
CAS No.: 1426953-21-0
Purity:  98.51%
Target:  

ADC Payloads

Research Areas:  

Cancer

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .
2
Datopotamab deruxtecan (solution)
Datopotamab deruxtecan (solution)
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2 Cited Publications
Cat. No.: HY-141598
CAS No.: 2238831-60-0
Purity:  99.54%
Synonyms: DS-1062 (solution); Dato-DXd (solution)
Datopotamab deruxtecan (DS-1062) solution is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan solution consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan solution binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan solution disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan solution can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer .
1
sulfo-SPDB-DM4
sulfo-SPDB-DM4
0 Images
1 Cited Publications
Cat. No.: HY-101141
CAS No.: 1626359-59-8
Purity:  99.81%
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
1
MC-EVCit-PAB-MMAE
MC-EVCit-PAB-MMAE
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1 Cited Publications
Cat. No.: HY-154915
CAS No.: 2873452-49-2
Purity:  99.04%
Target:  

Drug-Linker Conjugates for ADC Microtubule/Tubulin

Research Areas:  

Cancer

MC-EVCit-PAB-MMAE (Linker-Payload 11) is a drug-linker conjugates for ADC. MC-EVCit-PAB-MMAE contains the ADCs linker (MC-EVCit-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162) .
1
Patritumab deruxtecan
Patritumab deruxtecan
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1 Cited Publications
Cat. No.: HY-P99813
CAS No.: 2227102-46-5
Synonyms: HER3-DXd; U3-1402
Target:  

Antibody-Drug Conjugates (ADCs)

Research Areas:  

Cancer

Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .
7-MAD-MDCPT
7-MAD-MDCPT
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Cat. No.: HY-132162
CAS No.: 765871-81-6
Purity:  98.80%
Target:  

ADC Payloads

Research Areas:  

Cancer

7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs) .
SGD-1882
SGD-1882
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Cat. No.: HY-101127
CAS No.: 1222490-34-7
Purity:  98.45%
Synonyms: PBD dimer
Target:  

ADC Payloads

Research Areas:  

Cancer

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
Nampt-IN-10 TFA
Nampt-IN-10 TFA
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Cat. No.: HY-147193
CAS No.: 2567724-20-1
Purity:  98.70%
Target:  

NAMPT

Research Areas:  

Cancer

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .
AMG133 peptide payload TFA
AMG133 peptide payload TFA
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Cat. No.: HY-P10736A
Target:  

GCGR

Research Areas:  

Metabolic Disease

AMG133 peptide payload TFA is a GLP-1 analog agonist peptide. AMG133 peptide payload TFA potently activates GLP-1R and exhibits weight loss and metabolic improvement activities. AMG133 peptide payload TFA can be used for the synthesis of AMG 133 (HY-164535) .
AMG133 peptide payload
AMG133 peptide payload
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Cat. No.: HY-P10736
Target:  

GCGR

Research Areas:  

Metabolic Disease

AMG133 peptide payload is a GLP-1 analog agonist peptide. AMG133 peptide potently activates GLP-1R, and exhibits weight loss and metabolic improvement activities. AMG133 peptide payload can be used for the synthesis of AMG 133 (HY-164535) .
Hemiasterlin
Hemiasterlin
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Cat. No.: HY-117371
CAS No.: 157207-90-4
Purity:  99.90%
Synonyms: (-)-Hemiasterlin; Milnamide B
Category:  

Alkaloids Animals Marine natural products Sponge Disease Research Fields Cancer Indole Alkaloids

Target:  

ADC Payloads

Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .
VcMMAE-Deruxtecan
VcMMAE-Deruxtecan
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Cat. No.: HY-164835
CAS No.: 2760408-75-9
Synonyms: VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418
Target:  

Drug-Linker Conjugates for ADC Microtubule/Tubulin Topoisomerase

Research Areas:  

Cancer

VcMMAE-Deruxtecan (VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418) is a drug-linker conjugate for ADC, composed of linker-payload molecule conjugate VcMMAE (HY-15575) and linker-payload molecule conjugate Deruxtecan (PAB-GGFG-AMAA)Exatecan) (HY-13631E). VcMMAE-Deruxtecan can be used in the synthesis of ADCs.
N-Me-L-Ala-maytansinol
N-Me-L-Ala-maytansinol
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Cat. No.: HY-126663
CAS No.: 77668-69-0
Purity:  99.89%
Target:  

ADC Payloads

Research Areas:  

Cancer

N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC) .
DIBAC-GGFG-NH2CH2-Dxd
DIBAC-GGFG-NH2CH2-Dxd
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Cat. No.: HY-147363
CAS No.: 2758875-01-1
Purity:  99.69%
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Others

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
Genevant CL1
Genevant CL1
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Cat. No.: HY-46759
CAS No.: 1450888-71-7
Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines .
Assay Types