DIBAC-GGFG-NH2CH2-Dxd

Cat. No.: HY-147363 Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DIBAC-GGFG-NH2CH2-Dxd Chemical Structure

CAS No. : 2758875-01-1

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 7680	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates^[1]. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Molecular Weight

1128.16

Formula

C₆₁H₅₈FN₉O₁₂

CAS No.

2758875-01-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (88.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8864 mL	4.4320 mL	8.8640 mL
5 mM	0.1773 mL	0.8864 mL	1.7728 mL
10 mM	0.0886 mL	0.4432 mL	0.8864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (257 KB) HNMR (395 KB) RP-HPLC (274 KB) MS (77 KB)

Handling Instructions (2659 KB)

References

[1]. Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8864 mL	4.4320 mL	8.8640 mL	22.1600 mL
	5 mM	0.1773 mL	0.8864 mL	1.7728 mL	4.4320 mL
	10 mM	0.0886 mL	0.4432 mL	0.8864 mL	2.2160 mL
	15 mM	0.0591 mL	0.2955 mL	0.5909 mL	1.4773 mL
	20 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1080 mL
	25 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	30 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL
	40 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5540 mL
	50 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL
	60 mM	0.0148 mL	0.0739 mL	0.1477 mL	0.3693 mL
	80 mM	0.0111 mL	0.0554 mL	0.1108 mL	0.2770 mL