AMG133 peptide payload TFA
Based on 1 Customer Validation
AMG133 peptide payload TFA is a GLP-1 analog agonist peptide. AMG133 peptide payload TFA potently activates GLP-1R and exhibits weight loss and metabolic improvement activities. AMG133 peptide payload TFA can be used for the synthesis of AMG 133 (HY-164535).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.68%
- 화학식: C196H290BrN55O69.xC2HF3O2
- 분자량:4600.70 (free base)
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
AMG133 is a potent GLP-1R agonist, with EC50 values of 24.4 pM, 5.7 pM, 123 pM and 2.4 pM against human GLP-1R, cynomolgus monkey GLP-1R, mouse GLP-1R and rat GLP-1R, respectively[1].
AMG133 acts as a GIPR antagonist, with IC50 values of 42.4 nM, 26.5 nM, and 822.3 nM against human GIPR, cynomolgus monkey GIPR, and rat GIPR, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AMG 133 murine surrogate (0.5-2.5 mg/kg; i.p.; every 6 days; 3 doses total) produces sustained, dose-dependent body weight loss, reduced food intake, and improved metabolic parameters in diet-induced obese male mice[1].
AMG133 (0.25-0.75 mg/kg; s.c.; once weekly; 6 weeks) reduces body weight in obese male cynomolgus monkeys by 11% and 13% relative to baseline levels, respectively, while also decreasing energy intake and improving metabolic markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6N (male, 22 weeks of age, diet-induced obese)[1]
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Dosage:0.5 mg/kg; 2.5 mg/kg
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Administration:i.p.; every 6 days; 18 days
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Result:Produced significant body weight loss from day 1 through day 18, with a dose-dependent effect.
Reduced food intake in a dose-proportional manner, with the most pronounced reduction observed on days 0-3.
Induced significant decreases in blood glucose, plasma insulin, triglycerides, and total cholesterol compared to controls.
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Animal Model:Macaca fascicularis (male, BMI > 41 kg/m2, spontaneous obese)[1]
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Dosage:0.25 mg/kg; 0.75 mg/kg
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Administration:s.c.; once weekly; 6 weeks
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Result:Reduced body weight by 11% (0.25 mg/kg dose) and 13% (0.75 mg/kg dose) from baseline after 6 weeks of treatment.
Observed dose-dependent reduction in total energy intake in the first 3 weeks of dosing.
Significantly reduced fasting triglycerides, fasting insulin, total cholesterol, and low-density lipoprotein cholesterol levels from baseline in both dose groups.
Chemical Information
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Appearance Solid
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분자량 4600.70 (free base)
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화학식 C196H290BrN55O69.xC2HF3O2
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Color White to off-white
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Sequence
His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser-Lys(BrAc)-NH2
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Sequence Shortening
H-{Aib}-EGTFTSDYSSYLEEQAAKEFIAWLVKGGGGGGGSGGGGSGGGGS-Lys(BrAc)-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : ≥ 50 mg/mL
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
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Data Sheet (294 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
AMG133 peptide payload TFA Related Classifications
HY-P10736A Related Classifications
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