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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
photoaffinity labeling
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "photoaffinity labeling" in MCE Product Catalog:
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Cat. No.: HY-151662
CAS No.: 122590-77-6
Synonyms: N3-TFBA
Cat. No.: HY-145749
CAS No.: 2561483-27-8
PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells .
Cat. No.: HY-W782122
CAS No.: 1485490-47-8
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Photoclick cholesterol is a photoreactive cholesterol analog capable of undergoing click reactions. Photoclick cholesterol enables specific, saturable photoaffinity labeling of the mitochondrial translocator protein TSPO .
Cat. No.: HY-150063
CAS No.: 99330-28-6
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Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain .
Cat. No.: HY-151744
CAS No.: 1993119-45-1
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N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers . N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-147115
CAS No.: 79541-46-1
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4-Azidophlorizin is a high affinity probe and photoaffinity label for the glucose transporter in brush border membranes . 4-Azidophlorizin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-N15937
CAS No.: 2707415-27-6
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IKS02, a phosphatidylcholine (PC) phospholipid, is a photoaffinity labeling (PAL) probe .
Cat. No.: HY-123602
CAS No.: 152564-63-1
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CGP 55802A is a novel photoaffinity ligand for in situ labeling of NMDA receptors with high selectivity for the glutamate recognition site .
Cat. No.: HY-129927
CAS No.: 62020-54-6
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Thiomuscimol is a GABAA receptor agonist (IC50=19 nM). It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.
Cat. No.: HY-164910
CAS No.: 1838570-66-3
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AHL-Pu-2 is the clickable electrophilic purine. AHL-Pu-2 can be used to directly quantify protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells .
Cat. No.: HY-176056
CAS No.: 438488-95-0
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Hedgehog IN-9 (Compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents GLI1 expression and enhances cellular BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid cells and can be used for synthesis of photoaffinity labeling probe .
Cat. No.: HY-123761
CAS No.: 1374647-07-0
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L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of PS1-NTF, PS1-CTF, and SPP by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease .
Cat. No.: HY-W706341
CAS No.: 86992-52-1
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7,7-Azo-3-α,12-α-dihydroxycholanic acid is a photoinactive (photopolymerization) derivative of Cholic acid (HY-N0324), and it has a relatively low affinity for high-density lipoprotein (HDL) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
