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Cat. No.: HY-W782122

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Photoclick cholesterol

Photoclick cholesterol is a photoreactive cholesterol analog capable of undergoing click reactions. Photoclick cholesterol enables specific, saturable photoaffinity labeling of the mitochondrial translocator protein TSPO.
The product specifications provided below refer solely to the active content of Photoclick cholesterol.

For research use only. We do not sell to patients.

CAS No.: 1485490-47-8
Formula: C₃₀H₄₆N₂O₃
Molecular Weight:482.70

Storage:

Solution, -20°C, 2 years

Photoclick cholesterol Chemical Structure

CAS No.: 1485490-47-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Photoclick cholesterol is a photoreactive cholesterol analog capable of undergoing click reactions. Photoclick cholesterol enables specific, saturable photoaffinity labeling of the mitochondrial translocator protein TSPO^[1].
The product specifications provided below refer solely to the active content of Photoclick cholesterol.

In Vitro

Photoclick cholesterol (10-25 μM; 30 min dark incubation, 10 min UV irradiation) binds directly and competitively to native 18 kDa TSPO in mitochondria-enriched fractions from MA-10 mouse tumour Leydig cells, with increased labelling at 25 μM compared to 10 μM, and reduced labelling in the presence of 20- or 65-fold molar excess cholesterol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1485490-47-8
Appearance Liquid
Molecular Weight 482.70
Formula C₃₀H₄₆N₂O₃
Color Colorless to light yellow
SMILES

C[C@]12[C@@](C[C@H](CC2)O)([H])C3(N=N3)C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@H](C)CCC(OCCCCC#C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (587 KB)
- English - EN (587 KB)
- Français - FR (587 KB)
- Deutsch - DE (587 KB)
- Norwegian - NO (587 KB)
- Español - ES (587 KB)
- Swedish - SV (587 KB)
- Italian - IT (587 KB)
- Korean - KR (587 KB)
- Portuguese - PT (587 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Georges E, et al. Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue. J Biochem. 2021;170(2):239-243. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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