2561483-27-8

PARPYnD Chemical Structure
2561483-27-8

Chemical Structure

PARPYnD

  • CAS No.: 2561483-27-8
  • Formula:C34H31N9O3
  • Molecular Weight:613.67

IUPAC Name: 3-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)-N-(5-cyano-6-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)pyridin-3-yl)propanamide

InChIKey: ZYWZRMXOMDKHKX-UHFFFAOYSA-N

SMILES: N#CC1=CC(NC(CCC2(CCC#C)N=N2)=O)=CN=C1N3CCN(CC3)C(C4=CC=CC(CC5=NNC(C6=C5C=CC=C6)=O)=C4)=O

Biological Activity: PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells[1].

Cat. No. Product Name Purity Description Pricing
HY-145749 		PARPYnD 98.86% PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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