4-Azido-2,3,5,6-tetrafluorobenzoic Acid  (Synonyms: N3-TFBA)

4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) is a click chemistry reagent containing an azide group. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid is a complex with FAM-labeled DNA probe. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid can be used as versatile photoaffinity labeling agents to probe biological receptors. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

235.10

C₇HF₄N₃O₂

122590-77-6

Solid

White to off-white

523

489

[N-]=[N+]=NC1=C(C(F)=C(C(F)=C1F)C(O)=O)F

Room temperature in continental US; may vary elsewhere.

• [1]. Li G, et al. Multivalent photoaffinity probe for labeling small molecule binding proteins. Bioconjug Chem. 2014 Jun 18;25(6):1172-80.  [Content Brief]