1993119-45-1
Chemical Structure
N3-TFBA-O2Oc
- CAS No.: 1993119-45-1
- Formula:C13H12F4N4O5
- Molecular Weight:380.25
IUPAC Name: 2-(2-(2-(4-azido-2,3,5,6-tetrafluorobenzamido)ethoxy)ethoxy)acetic acid
InChIKey: SRPUVUGFIJXTIL-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NC1=C(C(F)=C(C(F)=C1F)C(NCCOCCOCC(O)=O)=O)F
Biological Activity: N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers[1][2][3]. N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N3-TFBA-O2Oc | N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers. N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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- [1]. Morris JL, et al. Aryl azide photochemistry in defined protein environments. Org Lett. 2013 Feb 15;15(4):728-31. [Content Brief]
- [2]. FLEET G, et al. Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group. Nature. 1969;224:511-512.
- [3]. Welle, et al. Tri- and tetravalent photoactivable cross-linking agents. Thieme. 2012;44(14):2249-2254.
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