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Results for "

ratiometric

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

19

Fluorescent Dye

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101897
    Fura-2 AM
    Maximum Cited Publications
    9 Publications Verification

    Fura-2 Acetoxymethyl ester

    		 Fluorescent Dye Others
    Fura-2 AM is a membrane permeable, intracellular, UV light-excitable and ratiometric fluorescent Ca 2+ (calcium ion) indicator. Fura-2 AM crosses cell membranes and is converted to Fura-2 (HY-D0110A) via cellular esterases. Fura-2 AM can be used to detect calcium in cells.
    Fura-2 AM
  • HY-125623
    MitoPerOx
    3 Publications Verification

    		 Fluorescent Dye Others
    MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].
    MitoPerOx
  • HY-DY1073
    MitoPerOx (solution)

    		Fluorescent Dye Others
    MitoPerOx (solution) is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state) , and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction) .
    Solvent and concentration: DMSO: 2 mM
    MitoPerOx (solution)
  • HY-D0077
    2',7'-Difluorofluorescein

    Oregon green 488

    		 Fluorescent Dye Others
    2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pKa ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca 2+ indicators, a fluorescent imaging agent, and an anisotropy probe .
    2',7'-Difluorofluorescein
  • HY-131013
    GSHtracer
    1 Publications Verification

    		 Fluorescent Dye Others
    GSHtracer is a ratiometric probe for measuring of GSH levels. GSHtracer exhibits Ex/Em from 520/580 nm to 430/510 nm (upon GSH binding) .
    GSHtracer
  • HY-D2312
    Mito-Rh-S

    		Fluorescent Dye Ferroptosis Cancer
    Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC) .
    Mito-Rh-S
  • HY-W110898
    Nile blue chloride

    		Fluorescent Dye Others
    Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics .
    Nile blue chloride
  • HY-126474
    MitoB bromide

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .
    MitoB bromide
  • HY-D2479
    DMANI

    		Fluorescent Dye Metabolic Disease
    DMANI is an intramolecular charge transfer (ICT)-based mitochondria-targeted ratiometric fluorescent probe. DMANI can monitor mitochondrial peroxynitrite (ONOO −) in living cells .
    DMANI
  • HY-131007
    FFN270 hydrochloride

    		Adrenergic Receptor Metabolic Disease
    FFN270 hydrochloride, a fluorescent tracer of norepinephrine, is a fluorescent substrate of the norepinephrine and vesicular monoamine transporters. FFN270 hydrochloride exhibits two resolved absorption/excitation maxima depending on solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm) and can function as ratiometric fluorescent pH-sensors .
    FFN270 hydrochloride
  • HY-W004617
    2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine

    4,4',4''-(1,3,5-Triazine-2,4,6-triyl)tribenzoic acid

    		 MOFs Others
    2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine (4,4',4''-(1,3,5-Triazine-2,4,6-triyl) tribenzoic acid) is a metal-organic framework. 2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine is a C3-symmetric organic ligand with temperature-sensitive ratioluminescent properties. Complexes derived from 2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine exhibit strong emissivity and can be used for highly sensitive ratiometric fluorescent temperature sensing .
    2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine
  • HY-D1752
    JC-9

    D-22421

    		 Fluorescent Dye Others
    JC-9 (D-22421) is a green-fluorescent probe used for ratiometric calculation of mitochondrial membrane potential.
    JC-9
  • HY-D1264
    PMQA

    Zn-green

    		 Fluorescent Dye Others
    PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn 2+-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn 2+ in living cells .
    PMQA
  • HY-143285
    AMC-GlcNAc

    		Fluorescent Dye Infection
    AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
    AMC-GlcNAc
  • HY-D2279
    NFL-NH2

    		Fluorescent Dye Inflammation/Immunology
    NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively .
    NFL-NH2
  • HY-D1257
    Msr-Ratio

    Msr-green

    		 Fluorescent Dye Others
    Msr-Ratio (Msr-green) is a ratiometric fluorescent probe of methionine sulfoxide reductase (λex=375 nm, λem=550 nm). Msr-Ratio is used for monitoring the enzyme activity in vitro and in live cells .
    Msr-Ratio
  • HY-137128
    BTC tetrapotassium

    		Fluorescent Dye Others
    BTC tetrapotassium is a cell-impermeant calcium indicator (Kd approximately 7-26 µM) featuring many desirable properties for cellular calcium imaging, including long excitation wavelengths (400/485 nm), low sensitivity to Mg 2+, and accuracy of ratiometric measurement .
    BTC tetrapotassium
  • HY-163386
    HFTC-HClO 1

    		Biochemical Assay Reagents Others
    HFTC-HClO 1 is a stable and sensitive ratiometric probe, which images the endogenous HClO. HFTC-HClO 1 exhibits a main emission peak at 579 nm. HFTC-HClO-1 visualizes HClO generated in the rheumatoid arthritis mouse model .
    HFTC-HClO 1
  • HY-126474S
    MitoB-d15 bromide

    		Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Inflammation/Immunology
    MitoB-d15 (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .
    MitoB-d15 bromide
  • HY-D2286
    HBT-Fl-BnB

    		Fluorescent Dye Others
    HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO - in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO - .
    HBT-Fl-BnB
  • HY-D3003
    M-H2S

    		Fluorescent Dye Others
    M-H2S is an endoplasmic reticulum-targeted ratio-type near-infrared fluorescent probe (Ex/Em : 480 nm/560 nm) specifically designed for the detection of hydrogen sulfide (H2S) in living cells and zebrafish. M-H2S exhibits detection limit for H2S of 39.1 nM, and the fluorescence intensity ratio (F₆₅₀/F₅₆₀) within the range of 0-40 μM shows a linear relationship with the H2S concentration. M-H2S responds best under pH = 7.2 (the normal physiological pH of the endoplasmic reticulum) conditions, making it suitable for the detection of the microenvironment of the endoplasmic reticulum. M-H2S can be used to study the role of H2S in endoplasmic reticulum function, stress response, and related diseases .
    M-H2S
  • HY-136675
    ASMI

    		Fluorescent Dye Others
    ASMI is a ratiometric, two-photon excited fluorescent probe, composed of a highly two-photon active and biocompatible merocyanine fluorophore and an acrylate moiety as a thiol reactive site. ASMI is able to selectively detect and monitor mitochondrial Cys with rapid responsiveness, imaging living cells and intact tissues with high contrast and brightness at a depth of 150 μm. The two-photon action cross section (Φσmax) of ASMI is 65.2 GM, corresponding to an excitation wavelength (λex) of 740 nm.
    ASMI
  • HY-D0121B
    INDO 1 pentasodium

    		Fluorescent Dye Others
    INDO 1 pentasodium is a cell-impermeant ratiometric, free calcium ion (Ca 2+) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca 2+ concentrations. When unbound to Ca 2+ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca 2+ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .
    INDO 1 pentasodium
  • HY-D3381
    MitoCLox

    		Fluorescent Dye Others
    MitoCLox is a mitochondria-targeted ratiometric fluorescent probe for measuring mitochondrial inner membrane lipid peroxidation .
    MitoCLox
  • HY-D3231
    Ratio-Coppersensor-1

    		Fluorescent Dye Others
    Ratio-Coppersensor-1 is a selective ratiometric copper ion Fluorescent reporter (excitation wavelength: 480 nm; emission peak central wavelengths at 505 nm and 570 nm, respectively). Ratio-Coppersensor-1 exhibits extremely high selectivity for Cu + at cellular concentrations, outperforming other competing metal ions, and shows an approximately 20-fold change in fluorescence ratio upon Cu + binding. Ratio-Coppersensor-1 is capable of reflecting changes in Cu levels .
    Ratio-Coppersensor-1
  • HY-D3166
    CEMT

    		Fluorescent Dye Others
    CEMT is a carboxylesterase (CE) substrate and a ratiometric two-photon fluorescent reporter probe. CEMT can be hydrolyzed by CE to generate HMT, which is used for mitochondrial pH sensing. After activation by CE, CEMT exhibits ratiometric fluorescence changes in response to pH variations. CEMT targets and covalently binds to mitochondria, and can avoid leakage during acidification, thus enabling in situ imaging .
    CEMT
  • HY-D2963
    R-MA-SLM

    		Fluorescent Dye Amyloid-β Neurological Disease
    R-MA-SLM is an Aβ-targeted and blood-brain barrier-permeable ratiometric H2O2-responsive fluorescent probe. When excited at 490 nm, the fluorescence intensity of the R-MA-SLM gradually decreases at 574 nm, while the emission intensity gradually increases at 661 nm. R-MA-SLM can detect and exhibits a ratiometric response to Aβ-induced endogenous H2O2. R-MA-SLM can be used in the research of Alzheimer's disease .
    R-MA-SLM
  • HY-175146
    Fura-2 leakage resistant AM

    		Fluorescent Dye Calcium Channel Others
    Fura-2 leakage resistant AM (Fura-PE3) is a new ratiometric calcium indicator. Fura-2 leakage resistant AM has calcium-binding characteristics (Kd = 146 nM) and fluorescent properties (emission: 510 nm; alternating excitation: 340 nm and 380 nm). Fura-2 leakage resistant AM monitors calcium concentration in platelet .
    Fura-2 leakage resistant AM
  • HY-185056
    Ferfluor-1

    		Ferroptosis Fluorescent Dye Cardiovascular Disease Neurological Disease
    Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models .
    Ferfluor-1
  • HY-DY1101
    Fura-2 AM (solution)

    Fura-2 Acetoxymethyl ester (solution)

    		 Fluorescent Dye Others
    Fura-2 AM (solution) (Fura-2 Acetoxymethyl ester (solution)) is a membrane permeable, intracellular, UV light-excitable and ratiometric fluorescent Ca 2+ (calcium ion) indicator. Fura-2 AM crosses cell membranes and is converted to Fura-2 (HY-D0110A) via cellular esterases. Fura-2 AM can be used to detect calcium in cells.
    Solvent and concentration: DMSO: 1 mM
    Fura-2 AM (solution)

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