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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
translation termination
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "translation termination" in MCE Product Catalog:
73
73 Publications Verification
Cat. No.: HY-K1057
Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.
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Anti-parasitic Disease Research Antibacterial Other Antibiotics Infection Microorganisms Plant Cell Culture Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields
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1 Cited Publications
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MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity .
Synonyms: PTC518
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Votoplam (PTC518) is a blood-brain barrier-permeable HTT pre-mRNA inhibitor with an IC50 ≤ 0.1 μM. Votoplam modulates the splicing process of HTT pre-mRNA to include a pseudo-exon carrying a premature translation termination codon, thereby triggering HTT mRNA degradation. Votoplam is applicable to research related to Huntington's disease .
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SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .
Cat. No.: HY-177569
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NVS1.1 is an orally active, blood-brain barrier-penetrant eRF1 degrader. NVS1.1 induces ubiquitination of eRF1 at Lys279, mediates proteasomal degradation via the E3 ubiquitin ligases RNF14 and RNF25 as well as the translational stress sensor GCN1, traps eRF1 at the ribosomal A-site, inhibits translation termination and triggers ribosome collision. As a readthrough enhancer, NVS1.1 enables near-cognate tRNA incorporation at premature termination codons by reducing intracellular eRF1 levels. NVS1.1 activates ribosome-associated quality control pathways via ribosome collision, including ubiquitination of small subunit ribosomal proteins. NVS1.1 restores functional full-length CFTR and IDUA proteins and reduces glycosaminoglycan accumulation in relevant models. NVS1.1 can be used in the research of cystic fibrosis and Hurler syndrome (mucopolysaccharidosis type I, MPS I) .
Cat. No.: HY-N0677AR
CAS No.: 76958-99-1
Synonyms: Potassium dehydroandrographolide succinate (Standard)
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Cat. No.: HY-P703566
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ETF1; Eukaryotic Peptide Chain Release Factor Subunit 1; Prev. ERF1; Polypeptide Chain Release Factor 1; Prev. SUP45L1; Protein Cl1; Prev. ERF; Eukaryotic Release Factor 1; TB3-1; D5S1995; RF1; Eukaryotic translation termination Factor 1; Sup45 (Yeast Omn
Cat. No.: HY-P702942
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ETF1; Eukaryotic Peptide Chain Release Factor Subunit 1; Prev. ERF1; Polypeptide Chain Release Factor 1; Prev. SUP45L1; Protein Cl1; Prev. ERF; Eukaryotic Release Factor 1; TB3-1; D5S1995; RF1; Eukaryotic translation termination Factor 1; Sup45 (Yeast Omn
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
