2421 Results for "

vitro

" in MedChemExpress (MCE) Product Catalog:
Products (2421)

2421 Results for "vitro" in MCE Product Catalog:

1197
Chloroquine phosphate
Chloroquine phosphate
0 Images
1197 Publications Verification
Cat. No.: HY-17589
CAS No.: 50-63-5
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Domaines de recherche:  

Infection Inflammation/Immunology Cancer

Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) .
1197
Chloroquine
Chloroquine
0 Images
1197 Publications Verification
Cat. No.: HY-17589A
CAS No.: 54-05-7
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Domaines de recherche:  

Infection Inflammation/Immunology Cancer

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) .
1197
Chloroquine dihydrochloride
Chloroquine dihydrochloride
0 Images
1197 Publications Verification
Cat. No.: HY-17589B
CAS No.: 3545-67-3
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Domaines de recherche:  

Infection Inflammation/Immunology Cancer

Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) .
755
Z-VAD-FMK
Z-VAD-FMK
0 Images
755 Cited Publications
Cat. No.: HY-16658B
CAS No.: 161401-82-7
Synonyms: Z-VAD(OH)-FMK
Target:  

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Domaines de recherche:  

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
221
Anti-Flag Magnetic Beads
Anti-Flag Magnetic Beads
0 Images
221 Cited Publications
Cat. No.: HY-K0207

MCE Anti-Flag Magnetic Beads are used for immunoprecipitation (IP) of specific Flag-tagged (DYKDDDDK) proteins expressed in bacterial and mammalian cells and in vitro expression systems, and also suitable for Co-immunoprecipitation and purification of Flag-tagged protein. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

199
Metformin hydrochloride
Metformin hydrochloride
0 Images
199 Cited Publications
Cat. No.: HY-17471A
CAS No.: 1115-70-4
Synonyms: 1,1-Dimethylbiguanide hydrochloride
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Domaines de recherche:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
199
Metformin
Metformin
0 Images
199 Cited Publications
Cat. No.: HY-B0627
CAS No.: 657-24-9
Synonyms: 1,1-Dimethylbiguanide
Target:  

AMPK Autophagy Mitophagy Apoptosis mTOR

Domaines de recherche:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
193
Chloroquine phosphate (Standard)
Chloroquine phosphate (Standard)
0 Images
193 Cited Publications
Cat. No.: HY-17589R
CAS No.: 50-63-5
Target:  

Reference Standards Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Domaines de recherche:  

Infection Inflammation/Immunology Cancer

Chloroquine (phosphate) (Standard) is the analytical standard of Chloroquine (phosphate). This product is intended for research and analytical applications. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) .
150
Anti-HA Magnetic Beads
Anti-HA Magnetic Beads
0 Images
150 Cited Publications
Cat. No.: HY-K0201

MCE Anti-HA Magnetic Beads are used for immunoprecipitation (IP) of specific HA-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

92
Colivelin
Colivelin
0 Images
92 Cited Publications
Cat. No.: HY-P1061
CAS No.: 867021-83-8
Target:  

STAT Amyloid-β

Domaines de recherche:  

Neurological Disease

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
92
Colivelin TFA
Colivelin TFA
0 Images
92 Cited Publications
Cat. No.: HY-P1061A
CAS No.: 2803948-60-7
Target:  

STAT Amyloid-β Apoptosis

Domaines de recherche:  

Neurological Disease

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .
88
Hydroxychloroquine sulfate
Hydroxychloroquine sulfate
0 Images
88 Cited Publications
Cat. No.: HY-B1370
CAS No.: 747-36-4
Synonyms: HCQ sulfate
Target:  

Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Domaines de recherche:  

Infection Cancer

Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .
79
DMOG
DMOG
0 Images
79 Cited Publications
Cat. No.: HY-15893
CAS No.: 89464-63-1
Pureté:  99.69%
Synonyms: Dimethyloxallyl Glycine
Target:  

HIF/HIF Prolyl-Hydroxylase Autophagy

Domaines de recherche:  

Cancer

DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation?in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG?acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
77
Anti-c-Myc Magnetic Beads
Anti-c-Myc Magnetic Beads
0 Images
77 Cited Publications
Cat. No.: HY-K0206

MCE Anti-c-Myc Magnetic Beads are used for immunoprecipitation (IP) of specific c-Myc-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

72
Mifepristone
Mifepristone
0 Images
72 Cited Publications
Cat. No.: HY-13683
CAS No.: 84371-65-3
Pureté:  99.83%
Synonyms: RU486; RU 38486
Target:  

Endogenous Metabolite Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy

Domaines de recherche:  

Endocrinology Cancer

Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay .
72
Mifepristone (Standard)
Mifepristone (Standard)
0 Images
72 Cited Publications
Cat. No.: HY-13683R
CAS No.: 84371-65-3
Pureté:  98.49%
Synonyms: RU486 (Standard); RU 38486 (Standard)
Target:  

Reference Standards Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy

Domaines de recherche:  

Endocrinology Cancer

Mifepristone (Standard) is the analytical standard of Mifepristone. This product is intended for research and analytical applications. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay .
60
Glycerol Monoleate
Glycerol Monoleate
0 Images
60 Cited Publications
Cat. No.: HY-N1446A
CAS No.: 25496-72-4
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery .
44
Hydroxychloroquine sulfate (Standard)
Hydroxychloroquine sulfate (Standard)
0 Images
44 Cited Publications
Cat. No.: HY-B1370R
CAS No.: 747-36-4
Synonyms: HCQ sulfate (Standard)
Target:  

Reference Standards Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Domaines de recherche:  

Infection Cancer

Hydroxychloroquine (sulfate) (Standard) is the analytical standard of Hydroxychloroquine (sulfate). This product is intended for research and analytical applications. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .
40
Atglistatin
Atglistatin
0 Images
40 Cited Publications
Cat. No.: HY-15859
CAS No.: 1469924-27-3
Pureté:  99.57%
Target:  

ATGL

Domaines de recherche:  

Metabolic Disease

Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor which inhibits lipolysis with an IC50 of 0.7 μM in vitro.
37
PKH 26
PKH 26
0 Images
37 Cited Publications
Cat. No.: HY-D1451
CAS No.: 154214-55-8
PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .
Assay Types