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warfarin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Calcium Channel (1) Cytochrome P450 (5) Drug Derivative (4) Drug Intermediate (1) Drug Metabolite (5) Endogenous Metabolite (2) Isotope-Labeled Compounds (4) Reference Standards (2) Sodium Channel (1) TrxR (1) VD/VDR (3) VKOR (1)
By Research Areas:	Cardiovascular Disease (3) Inflammation/Immunology (3) Metabolic Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015998

(R)-(+)-Warfarin	Biochemical Assay Reagents	Others
(R)-(+)-Warfarin is a biochemical assay reagent.

HY-N6678

Zearalanone 2 Publications Verification	Drug Metabolite	Metabolic Disease
Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin .

HY-B1042

Oxolamine citrate SKF-9976 citrate; AF-438 citrate	Cytochrome P450	Inflammation/Immunology
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive. Oxolamine citrate can inhibit CYP2B1/2. Oxolamine citrate has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine citrate increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine citrate can be used in respiratory disease research .

HY-139167

7-Hydroxywarfarin warfarin RC15	Drug Derivative	Others
7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity .

HY-W015998S

*(R)-(+)-Warfarin-d5*	Isotope-Labeled Compounds	Others
(R)-(+)-Warfarin-d₅ is deuterium labeled (R)-(+)-Warfarin.

HY-128720

Diethyl oxalpropionate	Endogenous Metabolite	Metabolic Disease
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .

HY-132569S

*8-Hydroxy warfarin-d5*	Isotope-Labeled Compounds Drug Metabolite	Others
8-Hydroxy warfarin-d₅ can be used as an internal standard for the quantification of Warfarin and its known metabolites .

HY-113958

Difethialone LM-2219	VD/VDR	Others
Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-113958R

Difethialone (Standard) LM-2219 (Standard)	TrxR Reference Standards	Others
Difethialone (Standard) is the analytical standard of Difethialone. This product is intended for research and analytical applications. Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-W741611

Dehydro Warfarin NSC 289346	Drug Metabolite	Metabolic Disease
Dehydro warfarin is a metabolite of (±)-warfarin. It is formed from (±)-warfarin by rat liver microsomes.

HY-159002S

*Methyl-warfarin-d3*	Isotope-Labeled Compounds	Cardiovascular Disease
Methyl-warfarin-d₃ is a deuterated labeling methylated Warfarin (HY-B0687) .

HY-W742809

(S)-7-Hydroxywarfarin	Drug Derivative	Others
(S)-7-Hydroxywarfarin is the S stereoisomer of 7-Hydroxywarfarin (HY-139167). (S)-7-Hydroxywarfarin is the inactive, major metabolite of racemic Warfarin (HY-B0687) .

HY-116601

6-Hydroxywarfarin	Cytochrome P450	Others
6-Hydroxywarfarin is a metabolite of (+) -warfarin. 6-Hydroxywarfarin is a weaker vitamin K antagonist. 6-Hydroxywarfarin is metabolized by the cytochrome P450 isomer 2C9 (CYP2C9) .

HY-121814A

(R)-Acenocoumarol (R)-Acenocoumarin; (R)-Nicoumalone	VD/VDR	Cardiovascular Disease
(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting and orally active anticoagulant, like Warfarin (HY-B0687), works by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol has a greater in vivo anticoagulant potency than Warfarin. (R)-Acenocoumarol has a single chiral center that produces two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 h) and a slower plasma clearance rate (1.9 L/h) than the (S)-enantiomer, resulting in a stronger in vivo anticoagulant effect.

HY-134999

10-Hydroxywarfarin	Drug Metabolite Cytochrome P450 VKOR	Metabolic Disease
10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC₅₀s of 1.6 µM and 80 ng/mL, respectively .

HY-B1717

Oxolamine	Cytochrome P450	Inflammation/Immunology
Oxolamine (SKF-9976) is an orally active antitussive. Oxolamine can inhibit CYP2B1/2. Oxolamine has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine can be used in respiratory disease research .

HY-113958S

Difethialone-d4 Baraki-d₄; LM 2219-d₄	Isotope-Labeled Compounds VD/VDR	Others
Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-121535

Levosemotiadil	Sodium Channel Calcium Channel	Others
Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .

HY-N7482

Pyranocoumarin	Drug Derivative	Others
Pyranocoumarin (Compound 13) is a heterocyclic scaffold (coumarin + pyran ring fusion). Pyranocoumarin inhibits the S-warfarin hydroxylation catalyzed by CYP2C9 .

HY-Z8242

3-(2-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one	Drug Intermediate	Others
3-(2-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one is a Warfarin (HY-B0687) impurity.

HY-139167R

7-Hydroxywarfarin (Standard)	Drug Derivative	Others
7-Hydroxywarfarin (Standard) is the analytical standard of 7-Hydroxywarfarin. This product is intended for research and analytical applications. 7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity .

HY-183649

BCN-PEG6-OH	Biochemical Assay Reagents	Cardiovascular Disease
BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy .

HY-128720R

Diethyl oxalpropionate (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
Diethyl oxalpropionate (Standard) is the analytical standard of Diethyl oxalpropionate. This product is intended for research and analytical applications. Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .

HY-167770

Chrysin 7-sulfate	Drug Metabolite	Metabolic Disease
Chrysin 7-sulfate is a conjugated metabolite of Chrysin (HY-14589). Chrysin 7-sulfate can strongly displace the Site I marker warfarin from human serum albumin. Chrysin 7-sulfate can effectively displace Ochratoxin A (OTA) (HY-N6788) from albumin both in vitro and in vivo .

HY-B1717A

Oxolamine hydrochloride	Cytochrome P450	Inflammation/Immunology
Oxolamine hydrochloride (SKF-9976 hydrochloride) is an orally active antitussive. Oxolamine hydrochloride can inhibit CYP2B1/2. Oxolamine hydrochloride has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine hydrochloride increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine hydrochloride can be used in respiratory disease research .

(R)-(+)-Warfarin	Biochemical Assay Reagents
(R)-(+)-Warfarin is a biochemical assay reagent.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6678

Zearalanone 2 Publications Verification	Structural Classification Classification of Application Fields Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology Source Classification	Drug Metabolite
Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin .

HY-128720

Diethyl oxalpropionate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .

HY-128720R

Diethyl oxalpropionate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Diethyl oxalpropionate (Standard) is the analytical standard of Diethyl oxalpropionate. This product is intended for research and analytical applications. Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .

Cat. No.	Product Name	Chemical Structure

HY-W015998S

*(R)-(+)-Warfarin-d5*
(R)-(+)-Warfarin-d₅ is deuterium labeled (R)-(+)-Warfarin.

HY-132569S

*8-Hydroxy warfarin-d5*
8-Hydroxy warfarin-d₅ can be used as an internal standard for the quantification of Warfarin and its known metabolites .

HY-159002S

*Methyl-warfarin-d3*
Methyl-warfarin-d₃ is a deuterated labeling methylated Warfarin (HY-B0687) .

HY-113958S

Difethialone-d4
Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

Difethialone-d4

Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

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warfarin

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products