83219-99-2
83219-99-2
Chemical Structure
10-Hydroxywarfarin
- CAS No.: 83219-99-2
- Formula:C19H16O5
- Molecular Weight:324.33
IUPAC Name: 4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one
InChIKey: BPZSPAZBZFZZBN-UHFFFAOYSA-N
SMILES: O=C1C(C(C2=CC=CC=C2)C(O)C(C)=O)=C(O)C3=CC=CC=C3O1
Biological Activity: 10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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10-Hydroxywarfarin | 99.9% | 10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively. | ||||||||||||||||||||
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References
- [1]. Shuhei Kobayashi, et al. Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J Thromb Thrombolysis. 2019 Apr;47(3):467-472. [Content Brief]
- [2]. Drew R Jones, et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23(5):939-45. [Content Brief]
