94820-66-3
94820-66-3
Chemical Structure
8-Hydroxy warfarin-d5
- CAS No.: 94820-66-3
- Formula:C19H11D5O5
- Molecular Weight:329.36
IUPAC Name: 4,8-dihydroxy-3-(3-oxo-1-(phenyl-d5)butyl)-2H-chromen-2-one
InChIKey: BHBOXPNWDGYJNB-QRKCWBMQSA-N
SMILES: CC(CC(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=C(C3=CC=CC(O)=C3OC2=O)O)=O
Biological Activity: 8-Hydroxy warfarin-d5 can be used as an internal standard for the quantification of Warfarin and its known metabolites[1].
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8-Hydroxy warfarin-d5 | 8-Hydroxy warfarin-d5 can be used as an internal standard for the quantification of Warfarin and its known metabolites. | |||||||||||||||||||||
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8-Hydroxywarfarin | 8-Hydroxywarfarin (8-OH Warfarin) is a CYP2C9 inhibitor. 8-Hydroxywarfarin inactivates the anticoagulant activity of Warfarin (HY-B0687) via 8-hydroxylation. 8-Hydroxywarfarin serves as a glucuronidation substrate for UGT1A1, UGT1A8, UGT1A9, as well as wild-type/mutant UGT1A10. This reaction enhances its polarity, solubility and excretion efficiency, and the process is independent of phenylalanine90 of UGT1A10. 8-Hydroxywarfarin can be used in studies related to thromboembolic diseases. | |||||||||||||||||||||
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References
