2,5-Dihydroxyterephthalic acid

2,5-Dihydroxyterephthalic acid acts as a ligand to form two MOFs with tetrahedral coordination geometry with Zn²⁺, and it can generate ligand-centered charge transfer green fluorescence in Zn²⁺-based MOFs^[1].
2,5-Dihydroxyterephthalic acid integrated Zn(II)-based MOFs (10-100 μmol/L; 24 h cytotoxicity incubation; 10 μmol/L; 4 h imaging incubation) exhibit distinct cytotoxicity and imaging features across multiple cancer cell lines: compound 1 exerts strong cytotoxicity against HeLa cells, while compound 2 possesses favorable biocompatibility with HeLa cells and enables clear fluorescence imaging of HeLa, SH-SY5Y and A549 cells; both compounds display concentration-dependent dual imaging and proliferation-inhibiting functions in SH-SY5Y cells^[1].
2,5-Dihydroxyterephthalic acid (compound 4) (1-10 μM; 15 min) exhibits strong antioxidant activity in cell-free assays, with an ORAC-FL value of 4.70 Trolox equivalents^[2].
2,5-Dihydroxyterephthalic acid exhibits no toxicity to BV-2 microglial cells at concentrations up to 10.0 μM, and shows weak inhibitory activity against LPS-induced NO and TNF-α production in these cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.