T-0156
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway.
For research use only. We do not sell to patients.
- CAS No.: 324572-93-2
- Formula: C31H30ClN5O7
- Molecular Weight:620.05
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE5 0.23 nM (IC50) |
PDE1 >100 μM (IC50) |
PDE2 >100 μM (IC50) |
PDE3 >100 μM (IC50) |
PDE4 63 μM (IC50) |
PDE6 56 nM (IC50) |
T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 324572-93-2
-
Molecular Weight 620.05
-
Formula C31H30ClN5O7
-
SMILES
COC(C(N1CC2=CC=NC(C)=C2)=C(C3=CC(OC)=C(OC)C(OC)=C3)C4=CC=NC(OCC5=NC=CC=N5)=C4C1=O)=O.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz