TAT-MEK1
TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM.
For research use only. We do not sell to patients.
- CAS No.: 566872-16-0
- Formula: C136H241N53O31S
- Molecular Weight:3146.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TAT-MEK1 (100 μM, 30 min) can inhibit luciferase activity in NIH.3T3 and PC12 cells , and inhibit the activation of ERK2sup>[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 and PC12
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Concentration:100 μM
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Incubation Time:30 min
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Result:Inhibited luciferase activity in cells and the activity of ERK2.
Chemical Information
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CAS No. 566872-16-0
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Molecular Weight 3146.77
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Formula C136H241N53O31S
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Sequence
Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
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Sequence Shortening
GYGRKKRRQRRRGMPKKKPTPIQLNP-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lukanowska M, et al. Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnol J. 2013 Aug;8(8):918-30. [Content Brief]
[2]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem. 2002 Mar 8;277(10):8741-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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