566872-16-0
Chemical Structure
TAT-MEK1
- CAS No.: 566872-16-0
- Formula:C136H241N53O31S
- Molecular Weight:3146.77
SMILES: O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCSC)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N3[C@@H](CCC3)C(N[C@@H]([C@H](O)C)C(N4[C@@H](CCC4)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N5[C@@H](CCC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM[1][2].
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TAT-MEK1 | TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM. | |||||||||||||||||||||
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- [1]. Lukanowska M, et al. Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnol J. 2013 Aug;8(8):918-30. [Content Brief]
- [2]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem. 2002 Mar 8;277(10):8741-8. [Content Brief]
Keywords
