2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TP003

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors.

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TP003

TP003 Chemische Struktur

CAS. Nr. : 628690-75-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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Beschreibung

TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors[1].

Molekulargewicht

407.39

Formel

C23H16F3N3O
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (245.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4547 mL 12.2733 mL 24.5465 mL
5 mM 0.4909 mL 2.4547 mL 4.9093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4547 mL 12.2733 mL 24.5465 mL 61.3663 mL
5 mM 0.4909 mL 2.4547 mL 4.9093 mL 12.2733 mL
10 mM 0.2455 mL 1.2273 mL 2.4547 mL 6.1366 mL
15 mM 0.1636 mL 0.8182 mL 1.6364 mL 4.0911 mL
20 mM 0.1227 mL 0.6137 mL 1.2273 mL 3.0683 mL
25 mM 0.0982 mL 0.4909 mL 0.9819 mL 2.4547 mL
30 mM 0.0818 mL 0.4091 mL 0.8182 mL 2.0455 mL
40 mM 0.0614 mL 0.3068 mL 0.6137 mL 1.5342 mL
50 mM 0.0491 mL 0.2455 mL 0.4909 mL 1.2273 mL
60 mM 0.0409 mL 0.2046 mL 0.4091 mL 1.0228 mL
80 mM 0.0307 mL 0.1534 mL 0.3068 mL 0.7671 mL
100 mM 0.0245 mL 0.1227 mL 0.2455 mL 0.6137 mL
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TP003 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP003628690-75-5TP 003TP-003GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorbenzodiazepineα1β2γ2α2β3γ2α3β3γ2α5β2γ2anxiolysisInhibitorinhibitorinhibit

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