2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. α5IA

α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential.

For research use only. We do not sell to patients.

α5IA Chemical Structure

α5IA Chemical Structure

CAS No. : 215874-86-5

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5 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

α5IA Related Antibodies

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Description

α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1].

In Vitro

α5IA (100 nM, 5 days) can significantly reduce Aβ 1-42-induced cell death in primary mouse hippocampal cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α5IA Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary mouse hippocampal culture
Concentration: 0.3 nM, 3 nM, 30 nM, 100 nM
Incubation Time: 24 h
Result: Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM.
Significantly decreased the expression of GABAAR α5 subunit.
In Vivo

α5IA (5 mg/kg, i.p., once) can sustain restoration of spatial learning ability in Ts65Dn mice, and long-term recognition of spatial memory deficits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

362.35

Formula

C17H14N8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1N=NC(COC(C2=C3C=CC=C2)=NN4C3=NN=C4C5=NOC(C)=C5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥97.0%

COA (251 KB)

Handling Instructions (2659 KB)
References
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α5IA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α5IA215874-86-5L-822179L822179L 822179GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAα5neuroprotectiveInhibitorinhibitorinhibit

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