1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. VEGFR
    Apoptosis
  3. VEGFR-IN-3

VEGFR-IN-3 

Cat. No.: HY-143293
Handling Instructions

VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer.

For research use only. We do not sell to patients.

VEGFR-IN-3 Chemical Structure

VEGFR-IN-3 Chemical Structure

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Description

VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.29 μM (OVCAR-4), 0.35 μM (MDA-MB-468), 25.9 μM (MCF-10A)[1]

In Vitro

VEGFR-IN-3 (10 μM; 60 min) inhibits a variety of cancer cell lines growth[1].
VEGFR-IN-3 (0-100 μM; 72 h) shows cytotoxic activities against MDA-MB-468 and OVCAR-4 cancer cell lines[1].
VEGFR-IN-3 (0.29-0.35 μM; 2.5 h) decreases the concentration of VEGF in OVCAR-4 and MDA-MB-468 cell lines[1].
VEGFR-IN-3 (0.29 μM; 48 h) increases levels of ERK1 and ERK2, activates ERK1 and ERK2 phosphorylation[1].
VEGFR-IN-3 (0.29 μM; 24 h) affects cell cycle and induces apoptosis of OVCAR-4 cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines
Concentration: 10 μM
Incubation Time: 60 min
Result: Showed significantly antiproliferative activities against Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines with GI% ranging from 49.1% to 98.46%.

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-468 and OVCAR-4 cancer cell lines, MCF-10A normal breast cancer cell line
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited MDA-MB-468, OVCAR-4 and MCF-10A cells growth with IC50 values of 0.35, 0.29 and 25.9 μM, respectively.

Apoptosis Analysis[1]

Cell Line: OVCAR-4 cell line
Concentration: 0.29 μM
Incubation Time: 24 hours
Result: Induced OVCAR-4 cells apoptosis by increasing the number of early and late apoptosis cells.

Cell Cycle Analysis[1]

Cell Line: OVCAR-4 cell line
Concentration: 0.29 μM
Incubation Time: 24 hours
Result: Arrested cell cycle in the S phase and increased the number of OVCAR-4 cells in pre-G1 phase.
Molecular Weight

476.52

Formula

C27H28N2O6

SMILES

CC(N(C(C1)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC)N=C1C4=CC(OC)=C(OC)C(OC)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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VEGFR-IN-3
Cat. No.:
HY-143293
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