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X5050 

Cat. No.: HY-136833
Handling Instructions

X5050 is a REST inhibitor, with an EC50 of 2.1 μM.

For research use only. We do not sell to patients.

X5050 Chemical Structure

X5050 Chemical Structure

CAS No. : 2404756-81-4

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Description

X5050 is a REST inhibitor, with an EC50 of 2.1 μM[1].

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NSCs.
Concentration: 100 µM.
Incubation Time: One day.
Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.
In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-week-old male C57Bl6 mice[1].2
Dosage: 2 x 2µl of 20 mM in 10% DMSO in water.
Administration: Intraventricular injection.
Result: Increased BDNF expression.
A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum.
Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.
Molecular Weight

309.32

Formula

C₁₇H₁₅N₃O₃

CAS No.

2404756-81-4

SMILES

O=C(C1=CC=C2N=C(C3=CC=CC=C3O)NC2=C1)NOCC=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

X5050X 5050X-5050OthersHuntingtondiseaseEmbryonicStemCellInhibitorinhibitorinhibit

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