1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
  3. 6-Chloromelatonin

6-Chloromelatonin 

Cat. No.: HY-100940
Handling Instructions

6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77).

For research use only. We do not sell to patients.

6-Chloromelatonin Chemical Structure

6-Chloromelatonin Chemical Structure

CAS No. : 63762-74-3

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Description

6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77)[1][2].

IC50 & Target[1]

MT1

8.9 (pKi)

MT2

9.1 (pKi)

In Vitro

6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM)[3].
6-chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 hours) inhibits, in a dose-dependent manner, forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

266.72

Formula

C₁₃H₁₅ClN₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
6-Chloromelatonin
Cat. No.:
HY-100940
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