63762-74-3
63762-74-3
Chemical Structure
6-Chloromelatonin
- CAS No.: 63762-74-3
- Formula:C13H15ClN2O2
- Molecular Weight:266.72
IUPAC Name: N-(2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl)acetamide
InChIKey: LUINDDOUWHRIPW-UHFFFAOYSA-N
SMILES: CC(NCCC1=CNC2=C1C=C(OC)C(Cl)=C2)=O
Biological Activity: 6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77)[1][2].
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6-Chloromelatonin | 6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77). | |||||||||||||||||||||
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References
- [1]. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000;129(5):877-886. [Content Brief]
- [2]. Clemens JA, et al. Inhibition of luteinizing hormone release and ovulation by 6-chloro- and 6-fluoromelatonin. Neuroendocrinology. 1980;30(2):83-87. [Content Brief]
Keywords
