62 Results for "

Amylin

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "Amylin" in MCE Product Catalog:

11
Rimegepant
Rimegepant
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11 Publications Verification
Cat. No.: HY-15498
CAS No.: 1289023-67-1
Purity:  99.94%
Synonyms: BMS-927711; BHV-3000
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .
3
Cagrilintide
Cagrilintide
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3 Cited Publications
Cat. No.: HY-P3462
CAS No.: 1415456-99-3
Target:  

CGRP Receptor

Research Areas:  

Metabolic Disease

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
3
Calcitonin (salmon)
Calcitonin (salmon)
0 Images
3 Cited Publications
Cat. No.: HY-P0090
CAS No.: 47931-85-1
Synonyms: Salmon calcitonin
Target:  

CGRP Receptor

Research Areas:  

Cancer

Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
2
Kp7-6
Kp7-6
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2 Cited Publications
Cat. No.: HY-P10102
CAS No.: 629628-53-1
Target:  

Apoptosis PERK NF-κB Caspase JNK

Research Areas:  

Inflammation/Immunology Cancer

Kp7-6 is a Fas mimetic peptide and also a Fas/FasL antagonist. Kp7-6 specifically binds to Fas and FasL, disrupts receptor complexes, and blocks downstream apoptosis signaling pathways. Kp7-6 inhibits the phosphorylation of ERK1-2, induces the phosphorylation of IκBα, and activates NF-κB. Kp7-6 inhibits the activation of caspase-8, caspase-3 and JNK, and suppresses human amylin-induced β-cell apoptosis. Kp7-6 inhibits FasL-induced lymphoid cytotoxicity and apoptosis. Kp7-6 reduces local tumor FasL expression, increases CD8 +Fas + T cell infiltration, and decreases tumor volume in pancreatic neuroendocrine tumor models. Kp7-6 prevents concanavalin A-induced liver injury in mice. Kp7-6 is applicable to research related to type 2 diabetes, concanavalin A-induced hepatitis and pancreatic neuroendocrine tumors .
2
6bK TFA
6bK TFA
0 Images
2 Cited Publications
Cat. No.: HY-110197
CAS No.: 1774353-12-6
Purity:  99.35%
Target:  

IDE

Research Areas:  

Metabolic Disease

6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .
1
Amylin, amide, rat
Amylin, amide, rat
0 Images
1 Cited Publications
Cat. No.: HY-P1464
CAS No.: 124447-81-0
Synonyms: Amylin (rat)
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.
Eloralintide
Eloralintide
0 Images
Cat. No.: HY-P10798
CAS No.: 2883634-40-8
Synonyms: LY-3841136
Target:  

Amylin Receptor Calcium Channel

Research Areas:  

Metabolic Disease

Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC50 23.9 pM and human AMY3R EC50 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium 2+ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .
Pramlintide
Pramlintide
0 Images
Cat. No.: HY-P0058
CAS No.: 151126-32-8
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease Cancer

Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .
AC 187
AC 187
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Cat. No.: HY-P1393
CAS No.: 151804-77-2
Target:  

Amylin Receptor

Research Areas:  

Endocrinology

AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects .
Petrelintide
Petrelintide
0 Images
Cat. No.: HY-P10745
CAS No.: 2766385-23-1
Synonyms: ZP8396
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .
Pramlintide acetate
Pramlintide acetate
0 Images
Cat. No.: HY-P0058B
CAS No.: 187887-46-3
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease Cancer

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer .
Eloralintide sodium
Eloralintide sodium
0 Images
Cat. No.: HY-P10798A
Synonyms: LY-3841136 sodium
Target:  

Amylin Receptor Calcium Channel

Research Areas:  

Metabolic Disease

Eloralintide sodium is an Amylin Receptor agonist. Eloralintide sodium selectively activates AMY1R and AMY3R in cells expressing human or rat AMY1R, AMY3R or CTR. Eloralintide sodium activates AMYRs and CTR in rats, inducing a sustained decrease in plasma Ca 2+ levels. Eloralintide sodium reduces appetite and body weight in both lean and obese rats. Eloralintide sodium can be used for research related to obesity .
Zenagamtide sodium
Zenagamtide sodium
0 Images
Cat. No.: HY-P11274A
Synonyms: Amycretin sodium; NN 9487 sodium
Target:  

Amylin Receptor Insulin Receptor GCGR

Research Areas:  

Metabolic Disease

Zenagamtide (Amycretin; NN 9487) sodium is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide sodium is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide sodium improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide sodium may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .
Petrelintide acetate
Petrelintide acetate
0 Images
Cat. No.: HY-P10745A
Synonyms: ZP8396 acetate
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .
NN1213 acetate
NN1213 acetate
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Cat. No.: HY-P11245A
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

NN1213 acetate, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC50 values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 acetate significantly reduces food intake and fat mass. NN1213 acetate can reduce body weightin diet-induced obese rats. NN1213 acetate can be used for the research of obesity .
Amylin, amide, human TFA
Amylin, amide, human TFA
0 Images
Cat. No.: HY-P1070A
Synonyms: DAP amide, human TFA
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent .
Colulintide
Colulintide
0 Images
Cat. No.: HY-P10956
CAS No.: 2891912-36-8
Synonyms: LY3541105
Target:  

Amylin Receptor CGRP Receptor

Research Areas:  

Metabolic Disease

Colulintide (LY3541105) is an amylin-calcitonin dual receptor agonist with Amylin as its scaffold. Colulintide is applicable to research related to type 2 diabetes and obesity .
Amylin, amide, human
Amylin, amide, human
0 Images
Cat. No.: HY-P1070
CAS No.: 122384-88-7
Synonyms: DAP amide, human
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent .
Calcitonin (8-32), salmon
Calcitonin (8-32), salmon
0 Images
Cat. No.: HY-P1782
CAS No.: 155069-90-2
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

Calcitonin (8-32), salmon is a highly selective Amylin receptor antagonist. Calcitonin (8-32), salmon reverses the Amylin-mediated inhibition of glucose-induced insulin release, but has no effect on either glucagon release or somatostatin release. Calcitonin (8-32), salmon can be used for studies related to β-cell amylin .
Zenagamtide
Zenagamtide
0 Images
Cat. No.: HY-P11274
CAS No.: 3005889-81-3
Synonyms: Amycretin; NN 9487
Target:  

Amylin Receptor GCGR Insulin Receptor

Research Areas:  

Metabolic Disease

Zenagamtide (Amycretin; NN 9487) is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .
Assay Types