1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3

CP21R7 (Synonyms: CP21)

Cat. No.: HY-100207 Purity: 99.52%
Handling Instructions

CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.

For research use only. We do not sell to patients.

CP21R7 Chemical Structure

CP21R7 Chemical Structure

CAS No. : 125314-13-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 348 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 948 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

View All GSK-3 Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.

IC50 & Target[1]

GSK-3β

1.8 nM (IC50)

PKCα

1900 nM (IC50)

In Vitro

CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.1512 mL 15.7560 mL 31.5119 mL
5 mM 0.6302 mL 3.1512 mL 6.3024 mL
10 mM 0.3151 mL 1.5756 mL 3.1512 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

317.34

Formula

C₁₉H₁₅N₃O₂

CAS No.

125314-13-8

SMILES

O=C1C(C2=CN(C)C3=CC=CC=C23)=C(C4=CC(N)=CC=C4)C(N1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CP21R7
Cat. No.:
HY-100207
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