1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR

CXCR2-IN-1 

Cat. No.: HY-101022 Purity: 98.81%
Data Sheet SDS Handling Instructions

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

For research use only. We do not sell to patients.
CXCR2-IN-1 Chemical Structure

CXCR2-IN-1 Chemical Structure

CAS No. : 1873376-49-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $367 In-stock
1 mg $150 In-stock
5 mg $350 In-stock
10 mg $600 In-stock
25 mg $1200 In-stock
50 mg $1950 In-stock
100 mg $3400 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

IC50 & Target

pIC50: 9.3 (CXCR2)[1]

In Vitro

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)[1].

In Vivo

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0993 mL 10.4965 mL 20.9930 mL
5 mM 0.4199 mL 2.0993 mL 4.1986 mL
10 mM 0.2099 mL 1.0496 mL 2.0993 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

Mouse: Mice are fed with cuprizone for 5 weeks to cause demyelinating lesions in the CNS and then orally administrated with CXCR2-IN-1 for 9 consecutive days at doses of 30 and 100 mg/kg twice daily[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

476.35

Formula

C₁₉H₂₀Cl₂FN₃O₄S

CAS No.

1873376-49-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥5.4 mg/mL (Need ultrasonic and warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CXCR2-IN-1
Cat. No.:
HY-101022
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