1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. CXCR2-IN-1

CXCR2-IN-1 

Cat. No.: HY-101022 Purity: 99.26%
Handling Instructions

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

For research use only. We do not sell to patients.

CXCR2-IN-1 Chemical Structure

CXCR2-IN-1 Chemical Structure

CAS No. : 1873376-49-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 367 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 367 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

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Description

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

IC50 & Target

CXCR2

9.3 (pIC50)

In Vitro

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

476.35

Formula

C₁₉H₂₀Cl₂FN₃O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.4 mg/mL (11.34 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0993 mL 10.4965 mL 20.9930 mL
5 mM 0.4199 mL 2.0993 mL 4.1986 mL
10 mM 0.2099 mL 1.0496 mL 2.0993 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice: Mice are fed with cuprizone for 5 weeks to cause demyelinating lesions in the CNS and then orally administrated with CXCR2-IN-1 for 9 consecutive days at doses of 30 and 100 mg/kg twice daily[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
CXCR2-IN-1
Cat. No.:
HY-101022
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