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Ravoxertinib hydrochloride

(Synonyms: GDC-0994 hydrochloride)
51 Cited Publications
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Based on 51 publication(s) in Google Scholar

Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.44%
  • CAS No.: 2070009-58-2
  • Formula: C21H19Cl2FN6O2
  • Molecular Weight:477.32
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Ravoxertinib hydrochloride Chemical Structure
    Ravoxertinib hydrochloride Chemical Structure
  • Experimental Validation Results for Ravoxertinib hydrochloride
  • Experimental Validation Results for Ravoxertinib hydrochloride
  • Experimental Validation Results for Ravoxertinib hydrochloride
  • Experimental Validation Results for Ravoxertinib hydrochloride
  • Experimental Validation Results for Ravoxertinib hydrochloride
  • Experimental Validation Results for Ravoxertinib hydrochloride
CAS No.: 2070009-58-2
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Ravoxertinib hydrochloride Chemical Structure
    Ravoxertinib hydrochloride Chemical Structure
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    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 21;17(1):1902. [Abstract]

    Customer Validation
     U87, U251, and H1299 cells, with or without EGFR R252C mutation were treated with or without 5 μM Ravoxertinib. Cell proliferation was assessed at day 7. Relative proliferation was calculated using vehicle-treated EGFR WT cells as the control.

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    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jan;637(8046):726-735. [Abstract]

    Customer Validation
     Investigation of the signalling axis regulating LIF expression upon PDGF stimulation. Cells were treated with ERK inhibitor ravoxertinib (10 μM) for 24 h before cell lysis for total RNA extraction and measurement of LIF mRNA levels by real-time qPCR.

  • 1/16

    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]

    Customer Validation
     Effects of kinase inhibitors on ISO-triggered inhibition of SeV-induced transcription of the IFNB1 gene. THP1 cells were treated with the ERK inhibitor GDC-0994 (1 μM) for 1 h and then were treated with ISO (10 μM) and infected with SeV (MOI = 1). Six hours later, a qPCR analysis to determine the mRNA levels of the IFNB1 gene was performed. The results are shown as the inhibition rate (%).

  • 1/16

    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 30;14(1):6117. [Abstract]

    Customer Validation
     HCT116 cells were pretreated with PPP (1 μM), ARQ-092 (2 μM) and GDC-0994 (Ravoxertinib, 10 μM) for 1 h before being cultured under hypoxia for 12 h.

  • 1/16

    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 Jul 13;42(1):166. [Abstract]

    Customer Validation
     The effect of NF-κB, ERK, JNK and p38 inhibitors on IL-1β-induced Saa3 expression in vivo. One hour after intravenous administration of Ravoxertinib, IL-1β (20 ng in 100 ul saline) were i.v. administrated into the mice. Six hours later, lung Saa3 expression was detected by qPCR.

  • 1/16

    Ravoxertinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 Jul 13;42(1):166. [Abstract]

    Customer Validation
     The effect of NF-κB, ERK, JNK and p38 inhibitors on IL-1β-induced Saa3 expression in MLE-12 cells. MLE-12 cells were pre-treated with Ravoxertinib for 1 h, then stimulated with IL-1β (10 ng/ml) for 6 h. Saa3 expression was detected by qPCR.

  • Ravoxertinib hydrochloride