1. Cell Cycle/DNA Damage
    NF-κB
  2. PPAR

GSK0660 

Cat. No.: HY-12377 Purity: 99.27%
Data Sheet SDS Handling Instructions

GSK0660 is a specific antagonist of PPARβ/δ, also has inverse agonist effects when used alone.

For research use only. We do not sell to patients.
GSK0660 Chemical Structure

GSK0660 Chemical Structure

CAS No. : 1014691-61-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $99 In-stock
50 mg $390 In-stock
100 mg $700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

GSK0660 is a specific antagonist of PPARβ/δ, also has inverse agonist effects when used alone. Target: PPARβ/δ in vitro: GSK0660 differentially regulates 273 transcripts in TNFα-treated cells compared to TNFα alone. GSK0660 blocks the TNFα-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNFα-induced retinal leukostasis. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9477 mL 23.8954 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL
10 mM 0.2390 mL 1.1948 mL 2.3895 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

418.49

Formula

C₁₉H₁₈N₂O₅S₂

CAS No.

1014691-61-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 49 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
GSK0660
Cat. No.:
HY-12377
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