1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Madrasin

Madrasin (Synonyms: DDD00107587)

Cat. No.: HY-100236 Purity: 99.88%
Handling Instructions

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.

For research use only. We do not sell to patients.

Madrasin Chemical Structure

Madrasin Chemical Structure

CAS No. : 374913-63-0

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5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
25 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Madrasin purchased from MCE. Usage Cited in: Nucleic Acids Res. 2019 Jun 19. pii: gkz532. 

    Western blot shows loss of POLR2A protein in Madrasin-treated cells. Cells are harvested after Madrasin treatment (30 μM) for 24 h.

    Madrasin purchased from MCE. Usage Cited in: Nucleic Acids Res. 2019 Jun 19. pii: gkz532. 

    Madrasin treatment leads to decrease of spliced POLR2A transcripts and accumulation of unspliced transcripts.

    Madrasin purchased from MCE. Usage Cited in: Nucleic Acids Res. 2019 Jun 19. pii: gkz532. 

    IF staining shows the loss of POLR2A protein after madrasin treatment. IF staining of POLR2A is performed after 24 h of Madrasin treatment at 30 uM. EU incorporation assay shows substantial reduction of newly transcribed RNA after Madrasin treatment. Assay is performed after 24 h of Madrasin treatment (30 μM).
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    Description

    Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

    Molecular Weight

    311.34

    Formula

    C₁₆H₁₇N₅O₂

    CAS No.

    374913-63-0

    SMILES

    O=C1N=C(NC2=NC(C)=C3C=CC(OC)=CC3=N2)NC(C)=C1C

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : < 0.1 mg/mL (insoluble)

    References
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    Product Name:
    Madrasin
    Cat. No.:
    HY-100236
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