1. GPCR/G Protein
  2. Adenosine Receptor
  3. APNEA

APNEA (Synonyms: N6-[2-(4-Aminophenyl)ethyl]adenosine)

Cat. No.: HY-18687 Purity: 97.19%
Handling Instructions

APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist.

For research use only. We do not sell to patients.

APNEA Chemical Structure

APNEA Chemical Structure

CAS No. : 89705-21-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg USD 228 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Description

APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist.

IC50 & Target

Adenosine receptor[1].

In Vitro

APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a non-selective agonist of the adenosine A3 receptors, at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiates the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at lower doses. APNEA (0.0039-1 mg/kg) also enhances the protective activity of carbamazepine. APNEA at low doses potentiates the protective activity of Carbamazepine most likely through the A subtype of adenosine receptors. At higher doses, APNEA seems to enhance the anticonvulsive effect of other antiepileptics via adenosine A1 receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine; 2-4 mg/kg) has no significant effect on seizure parameters (seizure severity, seizure duration and afterdischarge duration) in amygdala-kindled rats. N6-[2-(4-Aminophenyl)ethyl]adenosine is combined with antiepileptic drugs administered at doses ineffective in fully kindled rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

386.41

Formula

C₁₈H₂₂N₆O₄

CAS No.

89705-21-5

SMILES

OC[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]](N2C=NC3=C2N=CN=C3NCCC4=CC=C(N)C=C4)O1)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (129.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5879 mL 12.9396 mL 25.8792 mL
5 mM 0.5176 mL 2.5879 mL 5.1758 mL
10 mM 0.2588 mL 1.2940 mL 2.5879 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

APNEAN6-[2-(4-Aminophenyl)ethyl]adenosineAdenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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APNEA
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