1. GPCR/G Protein
    Neuronal Signaling
  2. GPR119
  3. PSN632408

PSN632408 

Cat. No.: HY-16673 Purity: 99.91%
Handling Instructions

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders.

For research use only. We do not sell to patients.

PSN632408 Chemical Structure

PSN632408 Chemical Structure

CAS No. : 857652-30-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 113 In-stock
Estimated Time of Arrival: December 31
5 mg USD 103 In-stock
Estimated Time of Arrival: December 31
10 mg USD 181 In-stock
Estimated Time of Arrival: December 31
50 mg USD 744 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].

In Vitro

PSN632408 produces concentration-dependent increases in cAMP level with mean EC50 value of 1.9 uM[1].
PSN632408 stimulates β cell replication in cultured mouse islets[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) rats[1]
Dosage: 100 mg/kg
Administration: P.o.; daily for 14 days
Result: The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss.
Molecular Weight

360.41

Formula

C₁₈H₂₄N₄O₄

CAS No.

857652-30-3

SMILES

O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (138.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7746 mL 13.8731 mL 27.7462 mL
5 mM 0.5549 mL 2.7746 mL 5.5492 mL
10 mM 0.2775 mL 1.3873 mL 2.7746 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PSN632408PSN 632408PSN-632408GPR119G protein coupled receptor 119betacellreplicationisletgraftfoodintakeobesityInhibitorinhibitorinhibit

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Product Name:
PSN632408
Cat. No.:
HY-16673
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