857652-30-3
Chemical Structure
PSN632408
- CAS No.: 857652-30-3
- Formula:C18H24N4O4
- Molecular Weight:360.41
IUPAC Name: tert-butyl 4-((3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methoxy)piperidine-1-carboxylate
InChIKey: LHZWKWCEAXQUMX-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2
Biological Activity: PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PSN632408 | 99.30% | PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders. | ||||||||||||||||||||
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- [1]. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. [Content Brief]
- [2]. Gao J, et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int. 2011;24(11):1124-1134. [Content Brief]
Keywords
