1. GPCR/G Protein
  2. GPR119
  3. APD597

APD597 (Synonyms: JNJ-38431055)

Cat. No.: HY-15566 Purity: 99.97%
Handling Instructions

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.

For research use only. We do not sell to patients.

APD597 Chemical Structure

APD597 Chemical Structure

CAS No. : 897732-93-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

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Description

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. IC50 value: 46 nM (EC50) [1] Target: hGPR119 The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1]

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 19 mg/mL (39.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0853 mL 10.4264 mL 20.8529 mL
5 mM 0.4171 mL 2.0853 mL 4.1706 mL
10 mM 0.2085 mL 1.0426 mL 2.0853 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    APD597 is prepare in vehicle (distilled water)[3].

References
Molecular Weight

479.55

Formula

C₂₁H₂₉N₅O₆S

CAS No.

897732-93-3

SMILES

O=C(OC(C)C)N(CC1)CCC1OC2=C(OC)C(NC3=CC=C(S(=O)(C)=O)N=C3C)=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.97%

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Product Name:
APD597
Cat. No.:
HY-15566
Quantity:

APD597

Cat. No.: HY-15566