897732-93-3
897732-93-3
Chemical Structure
APD597
Synonym(s): JNJ-38431055
- CAS No.: 897732-93-3
- Formula:C21H29N5O6S
- Molecular Weight:479.55
IUPAC Name: isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate
InChIKey: WPDCHTSXOPUOII-UHFFFAOYSA-N
SMILES: O=C(OC(C)C)N(CC1)CCC1OC2=C(OC)C(NC3=CC=C(S(=O)(C)=O)N=C3C)=NC=N2
Biological Activity: APD597 (JNJ-38431055) is an orally active agonist of GPR119. APD597 exhibits reduced CYP2C9 inhibition with an IC50 of 5.8 μM. APD597 can be studied in research for type 2 diabetes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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APD597 | 99.97% | APD597 (JNJ-38431055) is an orally active agonist of GPR119. APD597 exhibits reduced CYP2C9 inhibition with an IC50 of 5.8 μM. APD597 can be studied in research for type 2 diabetes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-18354GSK1104252A -
Similarity Score 0.56
HY-15565RAPD668 (Standard) -
Similarity Score 0.47
HY-15730Poziotinib -
Similarity Score 0.46
HY-163377AZ5385 -
Similarity Score 0.45
HY-13050Sapitinib -
Similarity Score 0.45
HY-124978MK-8282 -
Similarity Score 0.44
HY-163856CDK7-IN-30 -
Similarity Score 0.44
HY-117626LP-935509 -
Similarity Score 0.43
HY-184540ALK ligand-2 -
Explore the MedChemAI to find more analogs
References
- [1]. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335. [Content Brief]
- [2]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351. [Content Brief]
- [3]. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755. [Content Brief]
